Nano CBD and Liposomal CBD oil are thought to be water soluble and better absorbed by the body than regular CBD oils The whole point of liposomal CBD is to increase absorption & make CBD oil stronger. But does it work? What are the best liposomal CBD oils? Liposomal CBD supplements manufactured by LIPOSOMA contain specific additives based on Vitamin E in the bilayer that further increase liposome stability.
Why nano and liposomal CBD are a waste of money
While CBD appears to very beneficial to the body and mind, the natural substance is hard to absorb by the body. Leading to producers experimenting with techniques to increase the cannabinoid’s bioavailability. Some of these experiments are known as Nano CBD and Liposomal CBD oil. But we’re here to explain why these products don’t work and why you should stay away from them:
What is nano CBD oil?
Nano CBD is essentially nothing more than Cannabidiol (CBD) with a smaller particle size. This is made using ultrasonic frequencies; in order to bring the molecules of isolated CBD crystals – or a full spectrum hemp extract – to nano level-size. Producers and people selling this type of CBD oil often state that the bioavailability is many times higher compared to regular oils. Accordingly, sellers say this oil is also better absorbed by the body and is more effective because of that.
Though while CBD molecules from crystals and hemp extracts are indeed reduced in size with the use of ultrasonic frequencies; cannabidiol’s lipophilic properties remain the same in nano products. So, what does that mean for the bioavailability of the product? In other words, how does that affect the way the natural substance is processed by the body?
Effect of ‘full plant’ Nano CBD oil
Despite that Nano CBD is smaller than regular CBD, and therefor is easier to absorb by the body. It will still need to bind the nano particles to a lipoprotein to be properly processed. Resulting in a large part of the Nano CBD being broken down in the liver by P450-enzymes, before it can do any good in the body.
Furthermore, there are some major health-risks associated with this technique. Hence why Nano CBD is banned in many places. For example, you don’t want to ingest full plant hemp extracts at nano level. Because any heavy metals and pesticides present in the extract will also have been converted to nano parts; making it easier for these dangerous substances to reach the bloodstream. And it goes without saying that you don’t want this rubbish in your body.
Pure nano CBD from isolated crystals
Now, you might think ‘why not take nano CBD made with crystals, if that’s the problem?’ And we must admit, even considering the loss of cannabinoids while binding the CBD to lipoproteins to be properly processed; nano CBD from crystals might still be easier to absorb by the body compared to standard CBD oil. But it does have serious limitations…
As is the case with ‘Pure CBD oil’ based on crystals; nano CBD oil made with isolated cannabidiol is missing all the other active substances available in hemp. In other words, you’re missing the entourage effect; the synergy that happens in the body when cannabidiol is supported by other cannabinoids and terpenes. And here at Dutch Natural Healing, we strongly believe the entourage effect is one of the essential elements in CBD’s success.
Though there are governmental limitations too, which currently stand in the way of Nano CBD’s production and sales. EU food authorities for example, have indicated that Nano CBD is a NOVEL food and therefore may not be sold on the market without proper licenses. The authorities have also indicated they will maintain this ban across all Nano supplements in general; thereby including Nano CBD oil.
Liposomal CBD oil based on Lecithin / liposomes
Over the past few years, there’s also been an increase of CBD oils being sold based on lecithin. A substance naturally found in eggs, soy and sunflower seeds and is used, for example, to make mayonnaise. Lecithin is a so-called emulsifier-agent, meaning it binds fats to water. In CBD oil formulas, lecithin is thought to help the body absorb and process the active ingredients better.
To come to this conclusion, it is often compared to so-called liposomal vitamin C formulas. Where lecithin is also used to ensure the vitamin C is more effectively absorbed by the body. Lecithin makes sure fats can bind to certain enzymes in the body, resulting in them being effectively broken down. So at cell level, lecithin is essential for a healthy cell function. In that perspective, it’s safe to say lecithin is definitely a healthy food supplement. But will it actually aid the absorption of CBD in the body too?
Effects of liposomal CBD
So, we know that lecithin ensures the binding of fats (like CBD) to water, a process we refer to as emulsion. However, the binding of CBD with lecithin is a very difficult process. Moreover, the water solubility of lecithin at room temperature is very low. More importantly, lecithin’s binding power is stronger than that of the body’s own lipoprotein. What does that mean for the bioavailability?
As the lecithin ensures fats and fatty substances are strongly bound; lecithin is ideal to use as a natural cholesterol-reducer and as a slimming agent. Considering cannabinoids are also stored in fatty tissue, lecithin actually helps remove ‘stored’ CBD from the body at a faster pace. As lecithin binds to the CBD it encounters in the body; and ensures this is expelled from the body faster via the urinary tract. In other words, liposomal CBD literally helps you ‘piss away CBD’.
This does mean that you could effectively use lecithin to, for example, remove THC and other cannabinoids from your system. But it will definitely not help to achieve better CBD or THC absorption. As lecithin’s powerful fat binding properties means it has a counterproductive effect on the absorption of lipophilic substances such as CBD and THC. To conclude, liposomal CBD is even less effectively absorbed than regular CBD oil based on olive or hemp seed oil.
On the other hand, lecithin can in fact increase the absorption of water soluble substances – like vitamin C – in the body. This is referred to as a liposomal vitamin C solution. Using this, results in a higher concentration of the vitamin in the blood. Something that otherwise could only be reached through intravenous administration.
Safe and effective watersoluble CBD
Summarizing, nano CBD made from full plant hemp extracts could be dangerous. When it’s made from isolated crystals, it’s not more effective than regular oil, nor does it have a high bioavailability. On the other hand, lecithin can be used to increase the bioavailability of water soluble vitamins. But does not work with lipophilic (fat soluble) substances like THC and CBD!
Our unique CBDactive+ product however, is a whole other story. As it contains an advanced complex which is bound to the available cannabinoids; and acts like a lipoprotein (transporter) to the bloodstream. The bound CBD is therefore instantly water-soluble in CBDactive+.
As the cannabidiol is already bound to a lipoprotein thanks to the BioACTIVE+ Formula in the supplement; the body won’t need to carry out a complicated metabolization to get it into the bloodstream. This means your body will actually absorb 99% of the bound and water soluble CBD, in CBDactive+ products. Probably the highest bioavailability you’ll find in any CBD product available today.
Another advantage of CBDactive+ is that it contains all other cannabinoids and terpenes naturally present in hemp. This results in a full entourage effect and also offers a positive effect on the Cytochrome P450 enzyme system. Ensuring the active ingredients will be broken down even slower; giving your body more time to enjoy all the benefits CBD holds.
What is Liposomal CBD? Is it Worth The Money?
The whole point of liposomal CBD is to increase absorption & make CBD oil stronger. But does it work? What are the best liposomal CBD oils?
Liposomal cannabidiol is one of the most cutting-edge advancements when it comes to CBD products.
The CBD is placed in a microscopic “packaging,” called a liposome, that increases the bioavailability.
This means more of the CBD is available for your body to use.
Learn everything you need to know about liposomal CBD, including whether it’s right for you, in this article.
Table of Contents
What Is Liposomal CBD?
Liposomal cannabidiol, or liposomal CBD, refers to any CBD placed in liposomes before being packaged and sold.
The liposomes work to keep the CBD compound intact as it moves through your body, increasing bioavailability.
Bioavailability refers to the amount of a substance that’s able to go from the digestive tract to the blood, as well as the blood to the individual tissues.
Having a higher bioavailability makes a compound stronger and faster-acting.
What Are Liposomes?
Liposomes are microscopic “packaging,” that surrounds each individual molecule of a compound to protect it from normal bodily processes like digestion.
Liposomes are “sphere-shaped vesicles,” usually made of natural phospholipids — the molecules that make up our cell membranes — so they’re totally safe to ingest .
Liposomes are used for various medicines and vitamins to protect the compound from the point of ingestion all the way to absorption into the bloodstream. This doesn’t necessarily mean you’re getting 100% of the compound you’ve taken — your body almost always expels at least some of the compounds you ingest.
Note that not all medications can be liposomal. It works best with fat-soluble substances or minerals. CBD is fat-soluble and works great in liposomal form.
What Is Bioavailability?
The FDA defines bioavailability as an estimate of the fraction of the dose that is absorbed into the systemic circulation, a.k.a. the bloodstream.
Bioavailability is essentially the amount of a drug or other substance the body can actually “use.” It’s usually represented as a percentage.
The bioavailability of any substance depends on how it’s introduced to the body. Introducing a drug intravenously puts bioavailability at 100% because all of it enters the bloodstream.
When you take a substance orally or any other way, bioavailability can decrease due to the metabolic and digestive processes that are designed to break down the compounds we ingest.
Liposomes increase the bioavailability of CBD because they protect each CBD molecule from degrading during the digestion process. With the liposomal “packaging” around the compound, your body can take up more of the CBD inside rather than expelling some of it through urine or feces.
What Is The Bioavailability Of CBD?
It might shock you to learn that the bioavailability of most non-liposomal, oral CBD products is very low. CBD isn’t soluble in water, which can make it harder for your body to absorb the compound .
So, when you take a normal CBD gummy or tincture dose, a lot of the milligrams of CBD are filtered out during the metabolic process. This leaves the bioavailability of oral CBD at about 9% . For inhaled CBD products like vapes or flowers, bioavailability is greater — around 31% after smoking CBD .
Regardless of whether you choose to switch to liposomal CBD, it’s good to understand the approximate bioavailability of the products you like so you can have a better idea of how many milligrams of CBD your body is actually able to use.
However, keep in mind that bioavailability refers to the amount of the drug your body has the availability to take up — not necessarily the amount that actually moves into your bloodstream.
For instance, bioavailability can theoretically exceed 100%. That doesn’t mean your body would take up more than 100% of the drug that’s there, but rather that your body is available to move more than 100% of the drug into the bloodstream.
How Liposomal CBD Increases Bioavailability
Liposomal CBD increases the bioavailability of CBD by allowing the compound to stay in your system beyond the metabolic process, giving it time to absorb into your bloodstream, as we’ve covered.
The question is, how much of a difference do those liposomes really make?
A recent study compared liposomal and non-liposomal CBD, both taken orally . Forty percent of the patients who took the non-liposomal CBD had CBD in their blood one hour after ingestion. One hundred percent of the patients who took the liposomal CBD had CBD in their blood after the same period.
While there are limited studies on the increased bioavailability of liposomal CBD, the science is already there. Liposomes have been used since the 1960s for increased efficacy of tons of drugs and vitamins, all for the same reason that it’s being used for CBD now.
Compounds that are not fat or water-soluble simply need a little help getting into the bloodstream, and liposomes accomplish that.
Is Liposomal CBD Right For Me?
Despite the obvious benefits of liposomal CBD in terms of increased bioavailability, it might not be right for everyone. Because the technology is relatively cutting-edge within the world of cannabis, liposomal CBD products can be pricey and hard to find.
It’s also true that liposomal CBD isn’t really necessary if you prefer to take very low doses.
If a 50 mg dose of CBD is equivalent to around 25 mg of liposomal CBD, but the liposomal version is three times the price, it makes more sense to just use the standard CBD oil and take twice as much.
However, if you take very high doses of CBD, the price of liposomal CBD might start to feel worth it so you can get more out of the CBD you’re purchasing.
In terms of risk or difference in experience, liposomes will not impact your CBD in any way other than bioavailability. Liposomes are completely natural and non-toxic, and they’re designed to be absorbed into your blood. The only difference you might notice is higher efficacy; no additional side effects will take place .
Cannabidiol (CBD) is one of the several natural active ingredients of the Cannabis plant. It differs from tetrahydrocannabinol (THC) in that it lacks the well-known psychoactive effects .
Our liposomal supplements are superior in terms of effectiveness due to our proprietary formulation process and liposomal technology.
Our liposome experts have worked in clinical development of liposomal products, which require the highest quality standards.
Our liposomes are essentially non-toxic and biologically degradable.
Why Liposoma’s Liposomal CBD?
CBD is completely insoluble in water, poorly dissolves in alcohol and only dissolves well in oil. To be optimally absorbed in the intestines, CBD must be presented as individual molecules to the intestinal epithelial cells responsible for uptake of nutrients. In theory products with oily solutions could achieve this, but in practice the break up of an oil by the intestinal fluid and the process of dispersing it into tiny droplets ready for absorption is not straightforward and there are reports of poor bioavailability and high variability in uptake of CBD from oil products .
To make sure that CBD arrives in the gut in its active form, a solution is to incorporate it in liposomes, which are small, carefully designed phospholipid vesicles that form very stable dispersions in water . The phospholipids constitute a bilayer structure in which the CBD molecules can be safely kept dissolved, while at the same time they act as surfactants that help present them to the intestinal epithelial cells in the most optimal manner.
What is more, the liposomal supplements that are engineered by LIPOSOMA contain specific additives based on Vitamin E in the bilayer that further increase liposome stability and help protect its vulnerable contents against oxidation as well as attack of gastric fluids and enzymes.