Turmeric CBD oil combines the benefits of two of nature's most powerful healing herbs. Here's everything you need to know. Find out more about complementary medicines and the top five that people contact us about. Learn more about TURMERIC uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain TURMERIC.
CBD Oil with Turmeric – What Are the Benefits?
Several companies are now manufacturing CBD oil with turmeric. They market these products as combining the healing properties of two powerful natural remedies, both known for their anti-inflammatory effects.
So, what are the benefits of turmeric CBD oil, and what is the best way to use it? Here’s our complete guide.
What Is Turmeric CBD Oil?
Both turmeric and CBD come from plants with a long list of impressive qualities. Turmeric CBD oil blends the two into one convenient product with a wealth of potential benefits.
To better understand what turmeric CBD oil is and why people use it, let’s look at each ingredient in detail.
Turmeric comes from the root of a plant called Curcuma longa. Humans have used it for millennia, both as a culinary spice and medicinal herb. It has a deep golden color and a rich, earthy taste.
It is native to the Indian subcontinent, where it is a popular ingredient in curries and traditional Ayurvedic medicine. The plant also features heavily in the healing traditions of many other Asian countries.
Turmeric contains over 100 different compounds. However, one that truly stands out is a chemical called curcumin. Research has shown that curcumin has numerous positive effects on human health, including anti-inflammatory and antioxidant properties.
Over 3000 publications exist on turmeric to date, making it one of the best-studied natural remedies around. It appears to provide benefits to people with a range of medical conditions and healthy individuals alike.
Cannabidiol (CBD) is just one of the many active ingredients of Cannabis sativa plants, including marijuana and hemp. It is best known as the non-intoxicating counterpart to THC, providing benefits without a high.
Like turmeric, humans have used cannabis for its medicinal properties throughout history.
However, it became illegal during the 20th century, severely hindering research into its benefits. Fortunately, the situation is steadily improving, and studies are trickling through regarding both THC and CBD’s effects.
Research has revealed that the compound has potent antioxidant and anti-inflammatory properties. It is also neuroprotective, and proponents claim it can assist in a range of conditions, including anxiety, epilepsy, and pain.
Now that CBD is becoming more popular, many companies are trying to cash in. However, it takes a lot to stand out in such a crowded market place. This is why some brands are now combining their CBD oil with turmeric.
So, what is turmeric CBD oil good for? Let’s take a look.
What Is Turmeric CBD Oil Good for?
Turmeric and CBD oil share many of the same properties, although they work in different ways. Here are some of the most notable turmeric CBD benefits:
Probably the best-known effect of both CBD and turmeric is their mutual ability to quell inflammation. This makes the two substances highly desirable, as inflammation is the root cause of many ailments. It causes everything from the acute pain and swelling that occurs after an injury to chronic conditions like arthritis and eczema.
Inflammation also contributes to many long-term health problems, including heart disease, diabetes, and Alzheimer’s disease. Therefore, reducing inflammation is one of the best ways to stay healthy as we age. Could CBD and turmeric help?
A 2020 publication for the journal Antioxidants explains that CBD reduces inflammation via several distinct physiological pathways. Therefore, it shows potential in the treatment of a wide range of conditions. They include arthritis, cardiovascular disease, diabetes, Alzheimer’s, and skin diseases, to name a few.
Research into turmeric shows similar results. A 2017 review pointed to several studies that showed that curcumin could alleviate both osteoarthritis and rheumatoid arthritis symptoms. The review also offered evidence that curcumin appears to benefit people with metabolic syndrome, a complex disorder involving inflammation, obesity, diabetes, high blood pressure, and abnormal cholesterol and fat levels in the blood.
These findings mean that anyone wishing to tackle inflammation naturally could benefit from taking turmeric CBD oil. However, more research is necessary to confirm exactly how the two components work together and to what degree they can help.
Another common reason why people take CBD is to reduce anxiety. Several studies, such as this 2015 review for Neurotherapeutics, support this use. It states that CBD “has considerable potential” to relieve several different types of anxiety, including generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, and PTSD.
While people do not generally associate turmeric with reducing anxiety, it may have beneficial effects. A 2015 study for the Chinese Journal of Integrative Medicine looked at the effects of curcumin on 30 obese participants with anxiety and depression. It found that, after a month of treatment, curcumin reduced anxiety scores significantly. It is also unclear whether these results would be replicated in non-obese subjects, thus warranting further study.
The definitive guide to CBD oi…
Improving General Wellbeing
Turmeric CBD oil may also offer benefits to healthy individuals. Its antioxidant and anti-inflammatory properties mean that it could help to maintain general well-being and stave off disease.
There is a lack of research exploring the precise effects of CBD and turmeric on healthy volunteers. However, there is some evidence that CBD could reduce blood pressure and relieve stress.
Meanwhile, turmeric appears to have a diverse range of effects on healthy people. A 2012 study for Nutrition Journal looked at the effects of curcumin on healthy, middle-aged volunteers. It found that the compound positively influenced several markers indicating cardiovascular and cognitive health.
The researchers concluded that curcumin “produced a range of potentially health-promoting actions in healthy middle-aged people”.
How Do You Use Turmeric CBD Oil?
Consumers can use turmeric CBD oil in the same way as any other CBD tincture. The most effective method is to place a few drops under the tongue and hold it there for around a minute before swallowing.
Doing this allows the compounds to absorb into the bloodstream via the sublingual veins. It reduces the need for the oil to pass through the digestive system, where many beneficial compounds are lost.
To derive maximum benefit, there are a few other factors to take into account. Here’s how to choose the best CBD oil with turmeric.
What Is the Best Turmeric CBD Oil?
Unfortunately, both CBD and turmeric have low bioavailability, meaning that the body cannot absorb them easily. However, there are several ways to combat this.
Firstly, both curcumin and CBD are lipophilic, meaning they need some fat to help them absorb. Luckily, taking these compounds suspended in an oil automatically makes them more bioavailable. Different manufacturers use different oils as the base for their turmeric CBD oil. MCT oil is a popular choice as experts consider it to have one of the best absorption rates.
Secondly, CBD oils tend to come in three different varieties: full-spectrum, broad-spectrum, and isolate. Full-spectrum CBD contains a host of other cannabinoids and terpenes in addition to CBD, including traces of THC. Many people believe that it is the most effective option as these compounds work synergistically, a phenomenon called the entourage effect.
At the other end of the scale, CBD isolate contains almost pure CBD. Broad-spectrum falls somewhere between the two, as it includes a range of phytochemicals but no THC. The best type of CBD really boils down to personal preference. However, full-spectrum products potentially have an edge.
Explaining the difference in s…
Finally, for maximum benefit, choose a CBD oil with turmeric and black pepper. Black pepper is a bioenhancer and contains a chemical called piperine. A 1998 study for Planta Medica suggests that piperine enhances curcumin’s bioavailability by an incredible 2000%!
Turmeric CBD Oil Side Effects
CBD and turmeric are both relatively safe with a low risk of side effects. However, a small number of people experience adverse reactions, especially when taking high doses.
The most common side effects of CBD include:
- Dry mouth
- Digestive upsets
- Drug interactions
Furthermore, people taking large amounts of curcumin have reported:
Therefore, it is always best to start with a minimal turmeric CBD oil dose and build it up gradually over time. This can reduce the risk of side effects and also save money as it stops consumers from taking more than necessary to get results.
To learn more, check out our complete CBD dosage guide.
Final Thoughts on CBD Oil with Turmeric
Turmeric CBD oil combines the healing effects of two of nature’s most medicinal plants. It has powerful antioxidant and anti-inflammatory properties, meaning it could benefit a wide range of diseases. It also has the potential to promote general well-being in healthy individuals.
To get the most out of CBD oil with turmeric, look for products with a full range of cannabinoids and terpenes. The addition of black pepper will also mean that the body can utilize as much of turmeric’s curcumin as possible.
It is also essential to choose a reputable brand that provides lab reports and has clean extraction methods. This will ensure that the product contains everything it should and no contaminants, such as pesticides or solvents.
Finally, anyone in any doubt about whether turmeric CBD oil is safe for them should consult a physician before use.
Complementary treatments and arthritis – from turmeric to cannabis oil
People use complementary medicine for many different reasons, including:
- wanting to use more natural treatments
- their symptoms aren’t fully controlled by conventional medicine.
Read more about complementary therapies which can help to ease the symptoms of arthritis, from yoga to meditation.
Are they right for me?
As with all complementary treatments, different things work for different people and it isn’t possible to predict which might be the most useful or effective.
There are some key points to consider if you’re thinking about using any complementary treatments.
- What are you hoping to achieve? Pain relief? More energy? Better sleep? Reduction in medication?
- What are the financial costs?
- Is there any evidence for their effectiveness?
Are complementary medicines safe?
Complementary medicines are relatively safe, although you should always talk to your doctor before you start any new treatment.
In specific cases they may not be recommended, for example, if you are pregnant or breastfeeding, or they may interact with certain medication.
A starter for five
Here we share a spotlight on the most popular complementary medicines that people call our helpline about.
It’s thought that turmeric can possibly reduce inflammation, which could help people with arthritis.
People with knee osteoarthritis who took part in a research trial reported improvements to their pain levels after taking turmeric. The evidence is limited however, as it is from just one trial. What evidence there is suggested that people only had minor side-effects after taking turmeric.
Turmeric can be bought from health food shops, pharmacies and supermarkets in the form of powder.
Glucosamine sulphate and glucosamine hydrochloride are nutritional supplements. Animal studies have found that glucosamine can both delay the breakdown of and repair damaged cartilage.
The results for the use of glucosamine for osteoarthritis are mixed and the size of the effect is modest. There’s some evidence that more recent trials and those using higher-quality methods are less likely to show a benefit.
Capsaicin is taken from chilli peppers. It works mainly by reducing Substance P, a pain transmitter in your nerves. Results from randomised controlled trials assessing its role in treating osteoarthritis suggest that it can be effective in reducing pain and tenderness in affected joints, and it has no major safety problems. Evidence for its effectiveness for fibromyalgia is related to a single trial.
Other names: Axsain®, Zacin®, chilli, pepper gel, cayenne
Capsaicin is licensed in the UK for osteoarthritis and you can get it on prescription in the form of gels, creams and plasters.
There are no major safety concerns in applying capsaicin gel/cream. A review of capsaicin applied to the skin to treat chronic pain (not specifically related to osteoarthritis, rheumatoid arthritis or fibromyalgia) concluded that around one third of people experience a reaction around the area where the treatment is applied. It’s important to keep capsaicin away from your eyes, mouth and open wounds because it will cause irritation. There have been no reported drug interactions.
Fish oils are rich in omega-3 essential fatty acids, which have strong anti-inflammatory properties. Fish liver oil is also a rich source of vitamin A (a strong antioxidant) and vitamin D (which is important for maintaining healthy joints).
Evidence suggests that fish body oil can improve the symptoms of rheumatoid arthritis. Unconfirmed evidence also suggests a combination of fish body and liver oils might also be useful in the long term, particularly in reducing the use of non-steroidal anti-inflammatory drugs (NSAIDs). There isn’t enough evidence for the use of fish liver oil for osteoarthritis.
Omega-3 fatty acids also play a role in lowering cholesterol and triglyceride levels in your blood, so they can reduce the risk of heart disease and stroke in people with inflammatory arthritis.
In the UK, dietary guidelines recommend eating two portions of fish a week, including one oily. Fish oil is considered to be well tolerated at this dose.
At the correct doses, side-effects are usually minor and uncommon.
Cannabis oil (CBD)
CBD is type of cannabinoid – a natural substance extracted from the cannabis plant and often mixed with an oil (such as coconut or hemp) to create CBD oil. It does not contain the psychoactive compound called tetrahydrocannabidiol (THC) which is associated with the feeling of being ‘high’.
Research in cannabinoids over the years suggests that they can be effective in treating certain types of chronic pain such as pain from nerve injury, but there is currently not enough evidence to support using cannabinoids in reducing musculoskeletal pain. We welcome further research to better understand its impact and are intently following developments internationally.
CBD oil can be legally bought as a food supplement in the UK from heath food shops and some pharmacies. However, CBD products are not licensed as a medicine for use in arthritis by MHRA (Medicines and Healthcare products Regulatory Authority) or approved by NICE (National Institute for Health and Care Excellence) or the SMC (Scottish Medicines consortium).
We know anecdotally from some people with arthritis, that CBD has reduced their symptoms. If you’re considering using CBD to manage the pain of your arthritis, it’s important to remember it cannot replace your current medicines, and it may interact with them, so please do not stop/start taking anything without speaking to a healthcare professional.
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TURMERIC – Uses, Side Effects, and More
Turmeric is a common spice that comes from the root of Curcuma longa. It contains a chemical called curcumin, which might reduce swelling.
Turmeric has a warm, bitter taste and is frequently used to flavor or color curry powders, mustards, butters, and cheeses. Because curcumin and other chemicals in turmeric might decrease swelling, it is often used to treat conditions that involve pain and inflammation.
People commonly use turmeric for osteoarthritis. It is also used for hay fever, depression, high cholesterol, a type of liver disease, and itching, but there is no good scientific evidence to support most of these uses. There is also no good evidence to support using turmeric for COVID-19.
Don’t confuse turmeric with Javanese turmeric root or tree turmeric. Also, don’t confuse it with zedoary or goldenseal, which are unrelated plants that are sometimes called turmeric.
Uses & Effectiveness ?
Possibly Effective for
. Taking turmeric by mouth seems to reduce hay fever symptoms such as sneezing, itching, runny nose, and congestion.
- Depression. Most research shows that taking curcumin, a chemical found in turmeric, by mouth reduces depression symptoms in people already using an antidepressant.
- High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Taking turmeric by mouth seems to lower levels of blood fats called triglycerides. But the effects of turmeric on cholesterol levels are conflicting. Also, there are many different turmeric products available. It is not known which ones work best.
- Buildup of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Taking turmeric extract by mouth reduces markers of liver injury in people who have this condition. It also seems to help prevent the build-up of more fat in the liver.
- Swelling (inflammation) and sores inside the mouth (oral mucositis). Taking curcumin, a chemical found in turmeric, by mouth, or as a lozenge or mouthwash, seems to prevent swelling and sores in the mouth during radiation treatment for cancer.
- Osteoarthritis. Taking turmeric extracts, alone or together with other herbal ingredients, can reduce pain and improve function in people with knee osteoarthritis. Turmeric might work about as well as ibuprofen for reducing pain. But it doesn’t seem to work as well as another drug, called diclofenac.
- Itching. Taking turmeric by mouth might reduce itching that is caused by various conditions.
Possibly Ineffective for
. Taking turmeric, or a chemical in turmeric called curcumin, by mouth does not seem to improve symptoms of Alzheimer disease. ulcers. Taking turmeric by mouth does not seem to improve stomach ulcers.
When taken by mouth: Turmeric is likely safe when used short-term. Turmeric products that provide up to 8 grams of curcumin daily seem to be safe when used for up to 2 months, Also, taking up to 3 grams of turmeric daily seems to be safe when used for up to 3 months. Turmeric usually doesn’t cause serious side effects. Some people can experience mild side effects such as stomach upset, nausea, dizziness, or diarrhea. These side effects are more common at higher doses.
When applied to the skin: Turmeric is likely safe. It is possibly safe when turmeric is applied inside the mouth as a mouthwash.
When applied into the rectum: Turmeric is possibly safe when used as an enema.
Special Precautions and Warnings
When taken by mouth: Turmeric is likely safe when used short-term. Turmeric products that provide up to 8 grams of curcumin daily seem to be safe when used for up to 2 months, Also, taking up to 3 grams of turmeric daily seems to be safe when used for up to 3 months. Turmeric usually doesn’t cause serious side effects. Some people can experience mild side effects such as stomach upset, nausea, dizziness, or diarrhea. These side effects are more common at higher doses.
When applied to the skin: Turmeric is likely safe. It is possibly safe when turmeric is applied inside the mouth as a mouthwash.
When applied into the rectum: Turmeric is possibly safe when used as an enema.
Pregnancy: Turmeric is commonly used in small amounts as a spice in foods. But it’s likely unsafe to use larger amounts of turmeric as a medicine during pregnancy. It might cause a menstrual period or stimulate the uterus, putting the pregnancy at risk. Do not take medicinal amounts of turmeric if you are pregnant.
Breast-feeding: Turmeric is commonly used in small amounts as a spice in foods. But there isn’t enough reliable information to know if turmeric is safe to use in medicinal amounts during breast-feeding. Stay on the safe side and avoid use.
Gallbladder problems: Turmeric can make gallbladder problems worse. Do not use turmeric if you have gallstones or a bile duct obstruction.
Bleeding problems: Taking turmeric might slow blood clotting. This might increase the risk of bruising and bleeding in people with bleeding disorders.
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Turmeric contains a chemical called curcumin, which might act like the hormone estrogen. In theory, this might have effects on hormone-sensitive conditions. Until more is known, use cautiously if you have a condition that might be made worse by exposure to hormones.
Infertility: Turmeric might lower testosterone levels and decrease sperm movement. This might reduce fertility. Turmeric should be used cautiously by people trying to have a baby.
Liver disease: There is some concern that turmeric can damage the liver, especially in people who have liver disease. Don’t use turmeric if you have liver problems.
Surgery: Turmeric might slow blood clotting. It might cause extra bleeding during and after surgery. Stop using turmeric at least 2 weeks before a scheduled surgery.
Be cautious with this combination
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with TURMERIC
Turmeric might slow blood clotting. Taking turmeric along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Medications for diabetes (Antidiabetes drugs) interacts with TURMERIC
Turmeric might lower blood sugar levels. Taking turmeric along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Talinolol interacts with TURMERIC
Turmeric might decrease how much talinolol the body absorbs. Taking turmeric while taking talinolol might decrease the effects of talinolol.
Sulfasalazine (Azulfidine) interacts with TURMERIC
Turmeric might increase how much sulfasalazine the body absorbs. Taking turmeric while taking sulfasalazine might increase the effects and side effects of sulfasalazine.
Tacrolimus (Prograf) interacts with TURMERIC
Warfarin (Coumadin) interacts with TURMERIC
Warfarin is used to slow blood clotting. Taking turmeric while taking warfarin might increase the effects of warfarin and increase the risk of bleeding and bruising.
Medications for cancer (Alkylating agents) interacts with TURMERIC
Turmeric is an antioxidant. There is some concern that antioxidants might decrease the effects of some medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking turmeric.
Medications for cancer (Antitumor antibiotics) interacts with TURMERIC
Turmeric is an antioxidant. There is some concern that antioxidants might decrease the effects of medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking turmeric.
Medications for cancer (Topoisomerase I inhibitors) interacts with TURMERIC
Turmeric is an antioxidant. There is some concern that antioxidants might decrease the effectiveness of some medications used for cancers. If you are taking medications for cancer, check with your healthcare provider before taking turmeric.
Amlodipine (Norvasc) interacts with TURMERIC
Turmeric might increase how much amlodipine the body absorbs. Taking turmeric while taking amlodipine might increase the effects and side effects of amlodipine.
Medications that can harm the liver (Hepatotoxic drugs) interacts with TURMERIC
Turmeric might harm the liver. Some medications can also harm the liver. Taking turmeric along with a medication that can harm the liver might increase the risk of liver damage.
Tamoxifen (Nolvadex) interacts with TURMERIC
Turmeric might decrease how much tamoxifen is in the body. Taking turmeric with tamoxifen might decrease the effects of tamoxifen.
Be watchful with this combination
Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates) interacts with TURMERIC
Some medications are changed and broken down by the liver. Turmeric might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with TURMERIC
Some medications are changed and broken down by the liver. Turmeric might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with TURMERIC
Some medications are changed and broken down by the liver. Turmeric might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Estrogens interacts with TURMERIC
Large amounts of turmeric might interfere with the effects of estrogen. Taking turmeric along with estrogen might decrease the effects of estrogens.
Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Norfloxacin (Noroxin) interacts with TURMERIC
Turmeric might increase how much norfloxacin the body absorbs. Taking turmeric while taking norfloxacin might increase the effects and side effects of norfloxacin.
Medications moved by pumps in cells (P-Glycoprotein Substrates) interacts with TURMERIC
Some medications are moved in and out of cells by pumps. Turmeric might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Paclitaxel (Abraxane, Onxol) interacts with TURMERIC
Turmeric might change how much paclitaxel stays in the body. Taking turmeric while taking paclitaxel might change the effects and side effects of paclitaxel. However, this doesn’t seem to be a big concern.
Docetaxel (Taxotere) interacts with TURMERIC
Turmeric might increase how much docetaxel the body absorbs. Taking turmeric while taking docetaxel might increase the effects and side effects of docetaxel.
Glyburide (Diabeta, others) interacts with TURMERIC
Turmeric contains curcumin. Curcumin might lower blood sugar. Glyburide is also used to lower blood sugar. Taking curcumin or turmeric along with glyburide might cause your blood sugar to go too low. Monitor your blood sugar closely. Your dose of glyburide might need to be changed.
Turmeric has most often been used by adults in doses of up to 1.5 grams daily for up to 9 months. It is also sometimes used in mouthwashes, gels, creams, and tonics. Speak with a healthcare provider to find out what dose might be best for a specific condition.
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Choudhary, D., Chandra, D., and Kale, R. K. Modulation of radioresponse of glyoxalase system by curcumin. J Ethnopharmacol. 1999;64(1):1-7. View abstract.
Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., and Jirawatnotai, S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care 2012;35(11):2121-2127. View abstract.
Ciftci, O., Ozdemir, I., Tanyildizi, S., Yildiz, S., and Oguzturk, H. Antioxidative effects of curcumin, beta-myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver. Toxicol Ind Health 2011;27(5):447-453. View abstract.
Ciolino, H. P., Daschner, P. J., Wang, T. T., and Yeh, G. C. Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Biochem.Pharmacol. 7-15-1998;56(2):197-206. View abstract.
Cui, L., Miao, J., and Cui, L. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob.Agents Chemother. 2007;51(2):488-494. View abstract.
Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest 2009;119(7):2113. View abstract.
Dandekar, P. P., Jain, R., Patil, S., Dhumal, R., Tiwari, D., Sharma, S., Vanage, G., and Patravale, V. Curcumin-loaded hydrogel nanoparticles: application in anti-malarial therapy and toxicological evaluation. J Pharm Sci 2010;99(12):4992-5010. View abstract.
De, R., Kundu, P., Swarnakar, S., Ramamurthy, T., Chowdhury, A., Nair, G. B., and Mukhopadhyay, A. K. Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrob.Agents Chemother. 2009;53(4):1592-1597. View abstract.
Dorai, T., Cao, Y. C., Dorai, B., Buttyan, R., and Katz, A. E. Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 6-1-2001;47(4):293-303. View abstract.
Dou, X., Fan, C., Wo, L., Yan, J., Qian, Y., and Wo, X. Curcumin up-regulates LDL receptor expression via the sterol regulatory element pathway in HepG2 cells. Planta Med. 2008;74(11):1374-1379. View abstract.
El Agamy, D. S. Comparative effects of curcumin and resveratrol on aflatoxin B(1)-induced liver injury in rats. Arch.Toxicol 2010;84(5):389-396. View abstract.
Epelbaum, R., Schaffer, M., Vizel, B., Badmaev, V., and Bar-Sela, G. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr Cancer 2010;62(8):1137-1141. View abstract.
Eybl, V., Kotyzova, D., and Bludovska, M. The effect of curcumin on cadmium-induced oxidative damage and trace elements level in the liver of rats and mice. Toxicol Lett. 6-15-2004;151(1):79-85. View abstract.
Fan, C., Wo, X., Qian, Y., Yin, J., and Gao, L. Effect of curcumin on the expression of LDL receptor in mouse macrophages. J Ethnopharmacol. 4-21-2006;105(1-2):251-254. View abstract.
Fang, X. D., Yang, F., Zhu, L., Shen, Y. L., Wang, L. L., and Chen, Y. Y. Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp.Pharmacol Physiol 2009;36(12):1177-1182. View abstract.
Fiala, M., Liu, P. T., Espinosa-Jeffrey, A., Rosenthal, M. J., Bernard, G., Ringman, J. M., Sayre, J., Zhang, L., Zaghi, J., Dejbakhsh, S., Chiang, B., Hui, J., Mahanian, M., Baghaee, A., Hong, P., and Cashman, J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer’s disease patients are improved by bisdemethoxycurcumin. Proc.Natl.Acad.Sci.U.S A 7-31-2007;104(31):12849-12854. View abstract.
Flynn, D. L., Rafferty, M. F., and Boctor, A. M. Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones. Prostaglandins Leukot.Med. 1986;22(3):357-360. View abstract.
Frautschy, S. A., Hu, W., Kim, P., Miller, S. A., Chu, T., Harris-White, M. E., and Cole, G. M. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol.Aging 2001;22(6):993-1005. View abstract.
Funk, J. L., Frye, J. B., Oyarzo, J. N., Kuscuoglu, N., Wilson, J., McCaffrey, G., Stafford, G., Chen, G., Lantz, R. C., Jolad, S. D., Solyom, A. M., Kiela, P. R., and Timmermann, B. N. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 2006;54(11):3452-3464. View abstract.
Garcea, G., Berry, D. P., Jones, D. J., Singh, R., Dennison, A. R., Farmer, P. B., Sharma, R. A., Steward, W. P., and Gescher, A. J. Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol.Biomarkers Prev. 2005;14(1):120-125. View abstract.
Garcia-Alloza, M., Borrelli, L. A., Rozkalne, A., Hyman, B. T., and Bacskai, B. J. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem. 2007;102(4):1095-1104. View abstract.
Ghosh, A. K., Kay, N. E., Secreto, C. R., and Shanafelt, T. D. Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG. Clin Cancer Res 2-15-2009;15(4):1250-1258. View abstract.
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Gonda, R., Takeda, K., Shimizu, N., and Tomoda, M. Characterization of a neutral polysaccharide having activity on the reticuloendothelial system from the rhizome of Curcuma longa. Chem.Pharm Bull.(Tokyo) 1992;40(1):185-188. View abstract.
Gonda, R., Tomoda, M., Shimizu, N., and Kanari, M. Characterization of polysaccharides having activity on the reticuloendothelial system from the rhizome of Curcuma longa. Chem.Pharm Bull.(Tokyo) 1990;38(2):482-486. View abstract.
Gonda, R., Tomoda, M., Takada, K., Ohara, N., and Shimizu, N. The core structure of ukonan A, a phagocytosis-activating polysaccharide from the rhizome of Curcuma longa, and immunological activities of degradation products. Chem.Pharm Bull.(Tokyo) 1992;40(4):990-993. View abstract.
Gopalan, B., Goto, M., Kodama, A., and Hirose, T. Supercritical carbon dioxide extraction of turmeric (Curcuma longa). J Agric.Food Chem. 2000;48(6):2189-2192. View abstract.
Gota, V. S., Maru, G. B., Soni, T. G., Gandhi, T. R., Kochar, N., and Agarwal, M. G. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric.Food Chem 2-24-2010;58(4):2095-2099. View abstract.
Goto, H., Sasaki, Y., Fushimi, H., Shibahara, N., Shimada, Y., and Komatsu, K. Effect of curcuma herbs on vasomotion and hemorheology in spontaneously hypertensive rat. Am.J Chin Med. 2005;33(3):449-457. View abstract.
Grandjean-Laquerriere, A., Gangloff, S. C., Le Naour, R., Trentesaux, C., Hornebeck, W., and Guenounou, M. Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes. Cytokine 5-7-2002;18(3):168-177. View abstract.
Guimaraes, M. R., Coimbra, L. S., de Aquino, S. G., Spolidorio, L. C., Kirkwood, K. L., and Rossa, C., Jr. Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. J Periodontal Res 2011;46(2):269-279. View abstract.
Hanai, H., Iida, T., Takeuchi, K., Watanabe, F., Maruyama, Y., Andoh, A., Tsujikawa, T., Fujiyama, Y., Mitsuyama, K., Sata, M., Yamada, M., Iwaoka, Y., Kanke, K., Hiraishi, H., Hirayama, K., Arai, H., Yoshii, S., Uchijima, M., Nagata, T., and Koide, Y. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol.Hepatol. 2006;4(12):1502-1506. View abstract.
He, Z. Y., Shi, C. B., Wen, H., Li, F. L., Wang, B. L., and Wang, J. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Invest 2011;29(3):208-213. View abstract.
Hergenhahn, M., Soto, U., Weninger, A., Polack, A., Hsu, C. H., Cheng, A. L., and Rosl, F. The chemopreventive compound curcumin is an efficient inhibitor of Epstein-Barr virus BZLF1 transcription in Raji DR-LUC cells. Mol.Carcinog. 2002;33(3):137-145. View abstract.
Ho, S. C., Tsai, T. H., Tsai, P. J., and Lin, C. C. Protective capacities of certain spices against peroxynitrite-mediated biomolecular damage. Food Chem.Toxicol. 2008;46(3):920-928. View abstract.
Holt, P. R., Katz, S., and Kirshoff, R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig.Dis.Sci. 2005;50(11):2191-2193. View abstract.
Honda, S., Aoki, F., Tanaka, H., Kishida, H., Nishiyama, T., Okada, S., Matsumoto, I., Abe, K., and Mae, T. Effects of ingested turmeric oleoresin on glucose and lipid metabolisms in obese diabetic mice: a DNA microarray study. J Agric.Food Chem. 11-29-2006;54(24):9055-9062. View abstract.
Hu, G. X., Liang, G., Chu, Y., Li, X., Lian, Q. Q., Lin, H., He, Y., Huang, Y., Hardy, D. O., and Ge, R. S. Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3. Bioorg.Med.Chem.Lett. 4-15-2010;20(8):2549-2551. View abstract.
Hu, Y., Du, Q., and Tang, Q. [Determination of chemical constituents of the volatile oil from Curcuma longa by gas chromatography-mass spectrometry]. Se.Pu. 1998;16(6):528-529. View abstract.
Huang, C. Y., Chen, J. H., Tsai, C. H., Kuo, W. W., Liu, J. Y., and Chang, Y. C. Regulation of extracellular signal-regulated protein kinase signaling in human osteosarcoma cells stimulated with nicotine. J Periodontal Res 2005;40(2):176-181. View abstract.
Huang, H. C., Jan, T. R., and Yeh, S. F. Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. Eur.J Pharmacol. 10-20-1992;221(2-3):381-384. View abstract.
Huang, M. T., Deschner, E. E., Newmark, H. L., Wang, Z. Y., Ferraro, T. A., and Conney, A. H. Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol- induced colonic epithelial cell proliferation and focal areas of dysplasia. Cancer Lett. 6-15-1992;64(2):117-121. View abstract.
Huang, M. T., Lysz, T., Ferraro, T., Abidi, T. F., Laskin, J. D., and Conney, A. H. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 2-1-1991;51(3):813-819. View abstract.
Hussain, M. S. and Chandrasekhara, N. Effect on curcumin on cholesterol gall-stone induction in mice. Indian J Med.Res. 1992;96:288-291. View abstract.
Inano, H. and Onoda, M. Radioprotective action of curcumin extracted from Curcuma longa LINN: inhibitory effect on formation of urinary 8-hydroxy-2′-deoxyguanosine, tumorigenesis, but not mortality, induced by gamma-ray irradiation. Int.J Radiat.Oncol.Biol.Phys. 7-1-2002;53(3):735-743. View abstract.
Jain, S. K., Rains, J., Croad, J., Larson, B., and Jones, K. Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Antioxid.Redox.Signal. 2009;11(2):241-249. View abstract.
Jain, V., Prasad, V., Pal, R., and Singh, S. Standardization and stability studies of neuroprotective lipid soluble fraction obtained from Curcuma longa. J Pharm Biomed.Anal. 9-3-2007;44(5):1079-1086. View abstract.
Jayasekera, R., Freitas, M. C., and Araujo, M. F. Bulk and trace element analysis of spices: the applicability of k0-standardization and energy dispersive X-ray fluorescence. J Trace Elem.Med.Biol. 2004;17(4):221-228. View abstract.
Ji, H. F. and Shen, L. Interactions of curcumin with the PfATP6 model and the implications for its antimalarial mechanism. Bioorg.Med.Chem.Lett. 5-1-2009;19(9):2453-2455. View abstract.
Ji, M., Choi, J., Lee, J., and Lee, Y. Induction of apoptosis by ar-turmerone on various cell lines. Int.J Mol.Med. 2004;14(2):253-256. View abstract.
Jiang, H., Timmermann, B. N., and Gang, D. R. Use of liquid chromatography-electrospray ionization tandem mass spectrometry to identify diarylheptanoids in turmeric (Curcuma longa L.) rhizome. J Chromatogr.A 4-7-2006;1111(1):21-31. View abstract.
Joshi, J., Ghaisas, S., Vaidya, A., Vaidya, R., Kamat, D. V., Bhagwat, A. N., and Bhide, S. Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers. J Assoc.Physicians India 2003;51:1055-1060. View abstract.
Juan, H., Terhaag, B., Cong, Z., Bi-Kui, Z., Rong-Hua, Z., Feng, W., Fen-Li, S., Juan, S., Jing, T., and Wen-Xing, P. Unexpected effect of concomitantly administered curcumin on the pharmacokinetics of talinolol in healthy Chinese volunteers. Eur.J Clin Pharmacol 2007;63(7):663-668. View abstract.
Kalpana, C. and Menon, V. P. Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in Wistar rats. Ital.J Biochem. 2004;53(2):82-86. View abstract.
Kalpana, C. and Menon, V. P. Modulatory effects of curcumin on lipid peroxidation and antioxidant status during nicotine-induced toxicity. Pol.J Pharmacol 2004;56(5):581-586. View abstract.
Kanai, M., Imaizumi, A., Otsuka, Y., Sasaki, H., Hashiguchi, M., Tsujiko, K., Matsumoto, S., Ishiguro, H., and Chiba, T. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemother.Pharmacol 2012;69(1):65-70. View abstract.
Kaur, G., Tirkey, N., Bharrhan, S., Chanana, V., Rishi, P., and Chopra, K. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clin Exp.Immunol. 2006;145(2):313-321. View abstract.
Kawamori, T., Lubet, R., Steele, V. E., Kelloff, G. J., Kaskey, R. B., Rao, C. V., and Reddy, B. S. Chemopreventive effect of curcumin, a naturally occurring anti- inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res 2-1-1999;59(3):597-601. View abstract.
Khajehdehi, P., Zanjaninejad, B., Aflaki, E., Nazarinia, M., Azad, F., Malekmakan, L., and Dehghanzadeh, G. R. Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled study. J Ren Nutr 2012;22(1):50-57. View abstract.
Kheradpezhouh, E., Panjehshahin, M. R., Miri, R., Javidnia, K., Noorafshan, A., Monabati, A., and Dehpour, A. R. Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine. Eur.J Pharmacol 2-25-2010;628(1-3):274-281. View abstract.
Kiec-Swierczynska, M. and Krecisz, B. Occupational allergic contact dermatitis due to curcumin food colour in a pasta factory worker. Contact Dermatitis 1998;39(1):30-31. View abstract.
Kim, D. S., Park, S. Y., and Kim, J. K. Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult. Neurosci.Lett. 4-27-2001;303(1):57-61. View abstract.
Kim, H. J. and Jang, Y. P. Direct analysis of curcumin in turmeric by DART-MS. Phytochem.Anal. 2009;20(5):372-377. View abstract.
Kim, H. J., Yoo, H. S., Kim, J. C., Park, C. S., Choi, M. S., Kim, M., Choi, H., Min, J. S., Kim, Y. S., Yoon, S. W., and Ahn, J. K. Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication. J Ethnopharmacol. 7-15-2009;124(2):189-196. View abstract.
Kim, K., Kim, K. H., Kim, H. Y., Cho, H. K., Sakamoto, N., and Cheong, J. Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway. FEBS Lett. 2-19-2010;584(4):707-712. View abstract.
Koosirirat, C., Linpisarn, S., Changsom, D., Chawansuntati, K., and Wipasa, J. Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. Int Immunopharmacol. 2010;10(7):815-818. View abstract.
Korutla, L. and Kumar, R. Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochim.Biophys.Acta 12-30-1994;1224(3):597-600. View abstract.
Kusuhara, H., Furuie, H., Inano, A., Sunagawa, A., Yamada, S., Wu, C., Fukizawa, S., Morimoto, N., Ieiri, I., Morishita, M., Sumita, K., Mayahara, H., Fujita, T., Maeda, K., and Sugiyama, Y. Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP. Br J Pharmacol 2012;166(6):1793-1803. View abstract.
Kutluay, S. B., Doroghazi, J., Roemer, M. E., and Triezenberg, S. J. Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology 4-10-2008;373(2):239-247. View abstract.
Kuwabara, N., Tamada, S., Iwai, T., Teramoto, K., Kaneda, N., Yukimura, T., Nakatani, T., and Miura, K. Attenuation of renal fibrosis by curcumin in rat obstructive nephropathy. Urology 2006;67(2):440-446. View abstract.
Lamb, S. R. and Wilkinson, S. M. Contact allergy to tetrahydrocurcumin. Contact Dermatitis 2003;48(4):227. View abstract.
Lantz, R. C., Chen, G. J., Solyom, A. M., Jolad, S. D., and Timmermann, B. N. The effect of turmeric extracts on inflammatory mediator production. Phytomedicine. 2005;12(6-7):445-452. View abstract.
Lee, J. C., Kinniry, P. A., Arguiri, E., Serota, M., Kanterakis, S., Chatterjee, S., Solomides, C. C., Javvadi, P., Koumenis, C., Cengel, K. A., and Christofidou-Solomidou, M. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat.Res 2010;173(5):590-601. View abstract.
Leite, K. R., Chade, D. C., Sanudo, A., Sakiyama, B. Y., Batocchio, G., and Srougi, M. Effects of curcumin in an orthotopic murine bladder tumor model. Int.Braz.J Urol. 2009;35(5):599-606. View abstract.
Li, H., van Berlo, D., Shi, T., Speit, G., Knaapen, A. M., Borm, P. J., Albrecht, C., and Schins, R. P. Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line. Toxicol Appl.Pharmacol 2-15-2008;227(1):115-124. View abstract.
Li, W. Q., Dehnade, F., and Zafarullah, M. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. J Immunol. 3-1-2001;166(5):3491-3498. View abstract.
Li, W., Wang, S., Feng, J., Xiao, Y., Xue, X., Zhang, H., Wang, Y., and Liang, X. Structure elucidation and NMR assignments for curcuminoids from the rhizomes of Curcuma longa. Magn Reson.Chem. 2009;47(10):902-908. View abstract.
Li, W., Xiao, H., Wang, L., and Liang, X. [Analysis of minor curcuminoids in Curcuma longa L. by high performance liquid chromatography-tandem mass spectrometry]. Se.Pu. 2009;27(3):264-269. View abstract.
Li, Y. C., Wang, F. M., Pan, Y., Qiang, L. Q., Cheng, G., Zhang, W. Y., and Kong, L. D. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog.Neuropsychopharmacol.Biol.Psychiatry 4-30-2009;33(3):435-449. View abstract.
Lian, Q., Li, X., Shang, Y., Yao, S., Ma, L., and Jin, S. Protective effect of curcumin on endotoxin-induced acute lung injury in rats. J Huazhong.Univ Sci.Technolog.Med.Sci. 2006;26(6):678-681. View abstract.
Liddle, M., Hull, C., Liu, C., and Powell, D. Contact urticaria from curcumin. Dermatitis 2006;17(4):196-197. View abstract.
Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., and Cole, G. M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 11-1-2001;21(21):8370-8377. View abstract.
Lin, R., Chen, X., Li, W., Han, Y., Liu, P., and Pi, R. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neurosci.Lett. 8-8-2008;440(3):344-347. View abstract.
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Madden, K., Flowers, L., Salani, R., Horowitz, I., Logan, S., Kowalski, K., Xie, J., and Mohammed, S. I. Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. Prostaglandins Leukot.Essent.Fatty Acids 2009;80(1):9-18. View abstract.
Madkor, H. R., Mansour, S. W., and Ramadan, G. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. Br J Nutr 2011;105(8):1210-1217. View abstract.
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Mani, H., Sidhu, G. S., Kumari, R., Gaddipati, J. P., Seth, P., and Maheshwari, R. K. Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing. Biofactors 2002;16(1-2):29-43. View abstract.
Manzan, A. C., Toniolo, F. S., Bredow, E., and Povh, N. P. Extraction of essential oil and pigments from Curcuma longa [L] by steam distillation and extraction with volatile solvents. J Agric.Food Chem. 11-5-2003;51(23):6802-6807. View abstract.
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Meja, K. K., Rajendrasozhan, S., Adenuga, D., Biswas, S. K., Sundar, I. K., Spooner, G., Marwick, J. A., Chakravarty, P., Fletcher, D., Whittaker, P., Megson, I. L., Kirkham, P. A., and Rahman, I. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am.J Respir.Cell Mol.Biol. 2008;39(3):312-323. View abstract.
Meselhy, M. R. Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents. Phytochemistry 2003;62(2):213-218. View abstract.
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Moghaddam, S. J., Barta, P., Mirabolfathinejad, S. G., Ammar-Aouchiche, Z., Garza, N. T., Vo, T. T., Newman, R. A., Aggarwal, B. B., Evans, C. M., Tuvim, M. J., Lotan, R., and Dickey, B. F. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis 2009;30(11):1949-1956. View abstract.
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