Is CBD safe to use? Can CBD lead to withdrawals? To clear the the issue let's discuss CBD benefits, and how cannabidiol helps with withdrawals Medical cannabis and recreational marijuana users may not realize the headaches, dizziness, anxiety and other symptoms they feel between hits are signs of withdrawal. In healthy volunteers, no evidence of withdrawal syndrome was found with abrupt discontinuation of short-term treatment with CBD.
Can CBD Lead to Withdrawals?
CBD or cannabidiol is a relatively new alternative therapy popular for treating various health issues, including inflammation, epilepsy, depression, anxiety, and addictions.
However, with the rise in CBD popularity, people can’t stop but wonder about its safety. Is CBD safe to use? Can CBD lead to withdrawals?
To clear the confusion and answer your questions, in this post, we will focus on CBD, its benefits, and how cannabidiol helps with withdrawals.
What is CBD?
CBD comes from the cannabis plant (Cannabis Sativa or Cannabis Indica). It is the second most active component in cannabis and associated with various health benefits without the “high” effect, making it quite appealing to people looking for medical relief without the “stoned” feeling. In other words, CBD helps to neutralize or decrease the effect of THC.
How Does CDB Work on Your Body and Brain?
One of the many reasons why CBD is attractive is because it interacts with our endocannabinoid system. Cannabinoids regulate various psychological processes, such as the immune system, mood, stress, energy level, hunger, metabolism, bone density, and blood pressure. Therefore, our endocannabinoid system needs to operate efficiently without being overactive.
However, in almost every medical condition, the endocannabinoid system is greatly affected. CBD helps to balance and regulate the system by imitating the compound’s effects. As a result, it helps prevent any major breakdown in your body and brain, leading to disruption in your physical and mental functioning.
CBD and The Medical Benefits
When it comes to CBD and the medical perks it has, the list is extensive. Now that you know what CBD is and how it interacts with your endocannabinoid system, it is time to understand how it helps relieve stress, pain, and other effects of specific conditions and diseases.
CBD and Anxiety
CBD has an incredible effect on people suffering from stress and anxiety. According to the latest studies, CBD mimics and impacts our serotonin system, leading to relief from anxiety and making you feel more relaxed.
CBD and Pain
CBD also has impressive effects on people with acute or chronic pain. CBD helps with inflammatory and neuropathic pain and is an excellent alternative to use as a painkiller. It is not as addictive as pharmaceutical painkillers or opioids and may provide more considerable relief to specific issues.
CBD and Insomnia
People who find it challenging to sleep may discover alleviation with the help of this cannabidiol. Although there is not enough medical evidence that proves the correlation between CBD and sleep, there is a common agreement that it does play a role. In addition, a higher CBD dosage leads to prolonged and quality sleep.
It can also help you get rid of the issues or symptoms that keep you awake, for example, stress, anxiety, or pain.
CBD and Cancer
Cannabidiol has shown positive results in preventing some types of cancer, promoting cancer cell destruction, and suppressing cell growth. In fact, for some patients, CBD is more effective than other treatments such as chemotherapy.
CBD and Diabetes
The latest medical studies prove that CBD is helpful in Type 1 diabetes. During this condition, the immune system attacks the pancreas, which may lead to inflammation.
What Is the Right Dose For CBD?
There is no specific answer when it comes to CBD and dosage. Unlike antibiotics or other pharmaceutical drugs, you don’t get a prescription to consume two times a day. People usually determine CBD dosage by the problem they are dealing with and other factors such as consumption method, age, weight, and experience (beginner or active CBD consumer).
For example, a person with diabetes or epilepsy will require a higher dose than someone looking to relieve stress and anxiety. So, if you plan to start, we recommend beginning with a lower dosage and increasing according to your needs and issues.
Ways to Consume CBD
At SUPA Naturals, our mission is to help as many people as possible relieve their symptoms and improve their quality of life by providing high-quality CBD products. We are proud to work with non-GMO and organically grown hemp products to help you obtain CBD benefits without any side effects.
Here are some of the different ways to consume cannabidiol.
CBD tincture is one of the simplest ways to consume cannabidiol. It is a perfect option for people who don’t prefer the vape or smoke options or to wait for 30 to 45 minutes for the edibles to start working.
The idea is to use the dropper to apply the tincture under your tongue for more immediate effects.
CBD oil is another popular method to consume cannabidiol. It is similar to tinctures, with the only difference being the soaking time. CBD oil is more effective than tincture, although it has a bitter taste and no flavor.
At SUPA Naturals, we offer high-quality full-spectrum CBD oil, perfect for beginners and experienced consumers.
For people who want to be more discreet, edibles are your best option. You can add CBD to your favorite dessert or start your day with a CBD-infused tee. From gummies and chocolates to milkshakes, teas, and coffee, the list is endless when it comes to CBD edibles.
At SUPA Naturals, we offer non-GMO, organic, and tested CBD edibles in citrus and strawberry flavor.
CBD topicals are popular among athletes who treat sore muscles, pain, stress, or inflammation. Most topical products come in the form of balms, roll-ons, creams, and rubs.
CBD is quickly making its way into the beauty industry with CBD-based creams that help with acne trouble, skin repair, and collagen stimulation.
Smoking is one of the oldest ways of consuming cannabidiol. It was and still is the go-to way for those who want to enjoy the CBD benefits due to the feeling of relaxation and relief it provides. Smoking also leads to a faster and long-lasting effect.
Does Quitting CBD Cause Withdrawals?
As you can assume, many people are using CBD to help with their physical and mental health issues. However, they wonder what happens after they stop consuming cannabidiol.
Anti-depressants, painkillers, and other medications may cause withdrawal symptoms after you stop taking them. They modify your brain chemistry and function, and quitting them can cause your body to react. While CBD impacts the endocannabinoid system, it doesn’t have the same after-effect as anti-depressants and painkillers.
Medical experts and researchers have been analyzing cannabidiol, its efficacy, and safety. According to the latest studies, there are specific side effects from consuming CBD, but experts spotted no adverse effects after stopping with consumption. They have discovered that CBD can relieve withdrawal symptoms from other medications.
Cannabidiol can help with withdrawal symptoms from cigarettes, morphine, and heavy THC use. Until now, there is no specific answer to why CBD doesn’t cause withdrawals after you stop consuming it, but it may be because of how different cannabidiol is from anti-depressants, painkillers, and other drugs.
What Happens to Your Body When You Stop CBD Consumption?
Unlike many remedies and pharmaceuticals, cannabidiol doesn’t make you dependent, so it doesn’t pose any abuse risks. According to the World Health Organization, CBD is a safe alternative for many medications, including painkillers.
People also don’t build a tolerance to CBD as you might do with other drugs. Although these differences don’t explain why CBD doesn’t offer withdrawals, it does sum up how different cannabidiol is from other pharmaceuticals.
What might happen once you stop consuming CBD is that symptoms you were trying to cure or relieve may come back. However, unlike opiates and other medications, the resurfacing of your old symptoms (pain, inflammation, or sickness) shouldn’t feel as intense as before.
Effectiveness of CBD For Substance Addiction and Withdrawal
While the analysis and medical research are ongoing, the results collected show that CBD can help people combat substance addiction and withdrawals in a few ways.
CBD For Anxiety Due to Substance Abuse
Stress and anxiety can be a big problem for people struggling with substance addiction. It is one of those never-ending feelings and can significantly impact your quality of life.
For many people, using alcohol or drugs is a way to escape chronic physical or emotional pain, which in the long term can leave significant consequences. Attempting to break the cycle of drug or alcohol addiction with painkillers or anti-depressants can create an even higher level of anxiety.
CBD activates 5-HT1A or a serotonin receptor, which increases serotonin levels. Low levels of serotonin are linked to anxiety and depression and may impact your energy and mood. CBD affects the receptors, increases serotonin levels, and doesn’t provoke any side effects.
One of the most significant impacts CBD has for substance addiction treatment is PTSD or post-traumatic stress disorder. People who struggle with alcohol or drug abuse due to PTSD have found relief in CBD oil, tinctures, and topicals.
CBD For Opioid WIthdrawal
Lots of medical analysis on CBD’s use for withdrawal focuses on opiates such as heroin. While additional tests are necessary, the results experts have collected have shown that CBD reduces anxiety linked to heroin cravings.
Also, most prescribed anti-depressants and painkillers are opiates, and the chances of forming an addiction are high. CBD can help relieve anxiety, stress, and pain without the potential of producing the same side effects.
CBD For Alcohol Addiction
Unfortunately, alcoholism is a common condition in today’s society. Due to the high availability and accessibility of alcohol, more and more people struggle with alcohol addiction.
Alcoholism decreases the level of CB1 receptors, lowers your natural endocannabinoids, and impacts the function of neurotransmitters. CBD stimulates the number of CB1 receptors, helping your body recover and enabling you to return to healthier functioning.
Some studies reveal that CBD may also stop the damage in your brain and liver. Of course, more research is necessary, but these studies are promising in terms of CBD to help people with alcohol addiction.
How to Consume CBD for Substance Addiction and Withdrawal
Whether you are struggling with drug or alcohol addiction, want to reduce anxiety due to painkillers or anti-depressants abuse, or alleviate withdrawal symptoms, cannabidiols may help.
Before you start using CBD oil, tinctures, or edibles for withdrawal symptoms or substance addiction, it is vital to consult with your doctor and discuss your options.
CBD is generally safe, but it may interact with some pharmaceuticals and cause nausea, irritability, and fatigue. If you want to make sure you are not at risk and avoid the common side effects, you’ll want to have all the information before starting with consumption.
There are different ways to consume CBD oil for opioid addiction and withdrawals (we already mentioned some of the most popular ones). What you decide will depend on what’s easy and comfortable for you. With so many different products, you are sure to find one that will work for you and will provide you with symptoms relief.
CBD oils and edibles are easy-to-consume and long-lasting options. They pass through the digestive system, and you may feel the effect after 30-45 minutes. However, you will feel the benefits (decreased stress, anxiety, and pain) for about 5-6 hours.
You can follow the typical CBD oil routine and consume a few drops every morning or every night. CBD oil drops and tinctures are the most straightforward options for beginners because of the dosage control they provide. The effects of tinctures take about 30 minutes to kick in and will last up to 4 hours.
A Final Word
At first, be open to explore the options and test the products. Make sure to monitor how you are feeling physically and mentally before and after CBD consumption. You may have to try a couple of products before you find the right one.
At SUPA Naturals, we offer a vast selection of organically grown CBD products. We create 100% pure products using carbon dioxide extraction to harvest the active cannabinoids. The team packs all of the products in a cGMP-compliant facility, ensuring cleanliness, safety, and potency with each batch.
Don’t forget to check out our extensive list of products and explore our offers or get in touch with the team to obtain more information regarding our brand or CBD in general.
Frequently Asked Questions
Current research shows that most people do not experience withdrawal symptoms when they stop taking CBD. Other medications can cause withdrawal symptoms because while you are taking them, your brain chemistry is altered. Then when you stop, your body has an adverse reaction. CBD does not cause this effect.
You will not experience any withdrawal symptoms when you stop taking CBD. You will also not build a resistance or an addiction to CBD. You will be able to stop taking CBD at any time without any adverse effects. The only thing that will happen when you stop taking CBD is that your inflammation, pain, and anything else you were treating with CBD might come back.
While more research is needed, existing evidence shows that CBD can help ease the symptoms of withdrawals from other drugs and medications. Most of the time, stress and anxiety are the factors that drive the feelings of withdrawal. CBD can help ease stress and anxiety, which in turn can help reduce cravings and withdrawal symptoms.
More Than Half of People Using Cannabis for Pain Experience Multiple Withdrawal Symptoms
Minority experience worsening of symptoms over time, especially younger people.
More than half of people who use medical marijuana products to ease pain also experience clusters of multiple withdrawal symptoms when they’re between uses, a new study finds.
And about 10% of the patients taking part in the study experienced worsening changes to their sleep, mood, mental state, energy and appetite over the next two years as they continued to use cannabis.
Many of them may not recognize that these symptoms come not from their underlying condition, but from their brain and body’s reaction to the absence of substances in the cannabis products they’re smoking, vaping, eating or applying to their skin, says the University of Michigan Addiction Center psychologist who led the study.
When someone experiences more than a few such symptoms, it’s called cannabis withdrawal syndrome – and it can mean a higher risk of developing even more serious issues such as a cannabis use disorder.
In the new research published in the journal Addiction, a team from the University of Michigan Medical School and the VA Ann Arbor Healthcare System reports findings from detailed surveys across two years of 527 Michigan residents. All were participating in the state’s system to certify people with certain conditions for use of medical cannabis, and had non-cancer-related pain.
“Some people report experiencing significant benefits from medical cannabis, but our findings suggest a real need to increase awareness about the signs of withdrawal symptoms developing to decrease the potential downsides of cannabis use, especially among those who experience severe or worsening symptoms over time,” says Lara Coughlin, Ph.D., the addiction psychologist who led the analysis.
Long-term study in medical cannabis use
The researchers asked the patients whether they had experienced any of 15 different symptoms – ranging from trouble sleeping and nausea to irritability and aggression – when they had gone a significant time without using cannabis.
The researchers used an analytic method to empirically group the patients into those who had no symptoms or mild symptoms at the start of the study, those who had moderate symptoms (meaning they experienced multiple withdrawal symptoms) and those who had severe withdrawal issues that included most or all of the symptoms.
They then looked at how things changed over time, surveying the patients one year and two years after their first survey.
At baseline, 41% of the study participants fell into the mild symptoms group, 34% were in the moderate group and 25% were classed as severe.
Misconceptions about medical cannabis
Many people who turn to medical cannabis for pain do so because other pain relievers haven’t worked, says Coughlin, an Assistant Professor in the Department of Psychiatry who sees patients as part of U-M Addiction Treatment Services . They may also want to avoid long-term use of opioid pain medications because they pose a risk of misuse and other adverse health consequences.
She notes that people who experience issues related to their cannabis use for pain should talk with their health care providers about receiving other pain treatments including psychosocial treatments such as cognitive behavioral therapy.
The perception of cannabis as “harmless” is not correct, she says. It contains substances called cannabinoids that act on the brain – and that over time can lead the brain to react when those substances are absent.
In addition to a general craving to use cannabis, withdrawal symptoms can include anxiety, sleep difficulties, decreased appetite, restlessness, depressed mood, aggression, irritability, nausea, sweating, headache, stomach pain, strange dreams, increased anger and shakiness.
Previous research has shown that the more symptoms and greater severity of symptoms a person has, the less likely they are to be able to reduce their use of cannabis, quit using it or stay away from it once they quit.
They may mistakenly think that the symptoms happen because of their underlying medical conditions, and may even increase the amount or frequency of their cannabis use to try to counteract the effect – leading to a cycle of increasing use and increasing withdrawal.
“Our findings suggest a real need to increase awareness about the signs of withdrawal symptoms developing to decrease the potential downsides of cannabis use, especially among those who experience severe or worsening symptoms over time.”
Coughlin says people who decide to use a cannabis product for a medical purpose should discuss the amount, route of administration, frequency and type of cannabis product with their regular health provider. They should also familiarize themselves with the symptoms of cannabis withdrawal and tell their provider if they’re experiencing them.
Feeling the urge to use cannabis after a period without use, such as soon after waking up, can be a sign of a withdrawal syndrome, she notes. So can the inability to cut back on use without experiencing craving or other symptoms of withdrawal.
Because there is no medically accepted standard for medical cannabis dosing for different conditions, patients are often faced with a wide array of cannabis products that vary in strength and route of administration. Some products could pose more risk for development of withdrawal symptoms than others, Coughlin says. For example, people who smoked cannabis tended to have more severe withdrawal symptoms than others, while people who vaped cannabis reported symptoms that tended to stay the same or get worse, but generally did not improve, over time.
As more states legalize cannabis for medical or general use, including several states that will legalize its use based on the results of last November’s election, use is expected to grow.
More about the study
The researchers asked the patients about how they used cannabis products, how often, and how long they’d been using them, as well as about their mental and physical health, their education and employment status.
Over time, those who had started off in the mild withdrawal symptom group were likely to stay there, but some did progress to moderate withdrawal symptoms.
People in the moderate withdrawal group were more likely to go down in symptoms than up, and by the end of the study the number of the people in the severe category had dropped to 17%. In all, 13% of the patients had gone up to the next level of symptoms by the end of the first year, and 8% had transitioned upward by the end of two years.
Sleep problems were the most common symptom across all three groups, and many in the mild group also reported cravings for cannabis. In the moderate group, the most common withdrawal symptoms were sleep problems, depressed mood, decreased appetite, craving, restlessness, anxiety and irritability.
The severe withdrawal symptom group was much more likely to report all the symptoms except sweatiness. Nearly all the participants in this group reported irritability, anxiety, and sleep problems. They were also more likely to be longtime and frequent users of cannabis.
Those in the severe group were more likely to be younger and to have worse mental health. Older adults were less likely to go up in withdrawal symptom severity, while those who vaped cannabis were less likely to transition to a lower withdrawal-severity group.
The study didn’t assess nicotine use, or try to distinguish between symptoms that could also be related to breakthrough pain or diagnosed/undiagnosed mental health conditions during abstinence.
Coughlin and her colleagues hope future research can explore cannabis withdrawal symptoms among medical cannabis patients further, including the impact of different attempts to abstain, different types of use and administration routes, and interaction with other physical and mental health factors. Most research on cannabis withdrawal has been in recreational users, or “snapshot” looks at medical cannabis patients at a single point in time.
Further research could help identify those most at risk of developing problems, and reduce the risk of progression to cannabis use disorder, which is when someone uses cannabis repeatedly despite major impacts on their lives and ability to function.
The study was funded by the National Institute on Drug Abuse (DA033397). The original study from which the data came was led by Mark Ilgen, Ph.D., the Director of the U-M Addiction Treatment Services and a co-author of the new paper. The new study’s senior author is Kipling Bohnert, Ph.D., formerly of U-M and now at Michigan State University.
Paper cited: “Progression of cannabis withdrawal symptoms in people using medical cannabis for chronic pain,” Addiction. DOI: 10.1111/add.15370
Abrupt withdrawal of cannabidiol (CBD): A randomized trial
Rationale: The rationale of this study was to assess occurrence of withdrawal symptoms induced by abrupt cessation of cannabidiol (CBD) after prolonged administration in healthy volunteers.
Methods: Thirty volunteers were randomized to receive 750 mg of a plant-derived pharmaceutical formulation of highly purified CBD in oral solution (100 mg/mL; Epidiolex® in the United States and Epidyolex® in Europe) twice daily (b.i.d.) for 4 weeks (Part 1) followed by 2 weeks of 750 mg b.i.d. CBD (Part 2, Arm 1) or matched placebo (Part 2, Arm 2). All volunteers completed the Cannabis Withdrawal Scale (CWS) and the 20-item Penn Physician Withdrawal Checklist (PWC-20) on days -1, 21, 28, 31, 35, 42, and at follow-up.
Results: Median CWS and PWC-20 scores slightly decreased from Part 1 to Part 2. Median CWS scores ranged from 0.0 to 4.0 (out of a possible 190) in Arm 1 and 0.0 to 0.5 in Arm 2. Median PWC-20 scores were 0.0 (out of a possible 60) in both arms. Twenty-nine (97%) volunteers in Part 1 reported all-causality treatment-emergent adverse events (AEs); the most commonly reported was diarrhea (63%). In Part 2, Arm 1, 6 (67%) volunteers reported all-causality AEs; the most commonly reported was diarrhea (44%). In Part 2, Arm 2, 9 (75%) volunteers reported all-causality AEs; the most commonly reported was headache (58%). Nine volunteers withdrew because of AEs in Part 1; 1 withdrew in Part 2, Arm 2, because of an AE that began in Part 1. Four severe AEs were reported in Part 1; the remainder were mild or moderate. No serious AEs were reported.
Conclusion: In healthy volunteers, no evidence of withdrawal syndrome was found with abrupt discontinuation of short-term treatment with CBD.
Keywords: Cannabidiol; Cannabinoid; Drug withdrawal; Epilepsy; Seizure.
Copyright © 2020 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of competing interest All authors met the International Committee of Medical Journal Editors authorship criteria. Neither honoraria nor payments were made for authorship. Lesley Taylor was an employee of GW Research Ltd. at the time the work was completed. Julie Crockett is an employee of GW Research Ltd. and has share options in the company. Bola Tayo is an employee of GW Research Ltd. and owns shares in the company. Daniel Checketts is an employee of GW Research Ltd. Kenneth Sommerville was an employee of Greenwich Biosciences, Inc. at the time the work was completed.
Perry MS. Perry MS. Epilepsy Curr. 2019 Mar-Apr;19(2):93-95. doi: 10.1177/1535759719835671. Epilepsy Curr. 2019. PMID: 30955420 Free PMC article.
Ben-Menachem E, Gunning B, Arenas Cabrera CM, VanLandingham K, Crockett J, Critchley D, Wray L, Tayo B, Morrison G, Toledo M. Ben-Menachem E, et al. CNS Drugs. 2020 Jun;34(6):661-672. doi: 10.1007/s40263-020-00726-4. CNS Drugs. 2020. PMID: 32350749 Free PMC article. Clinical Trial.
Perkins D, Butler J, Ong K, Nguyen TH, Cox S, Francis B, Mcintosh M, Lilley B. Perkins D, et al. Eur J Drug Metab Pharmacokinet. 2020 Oct;45(5):575-586. doi: 10.1007/s13318-020-00624-6. Eur J Drug Metab Pharmacokinet. 2020. PMID: 32409982 Free PMC article. Clinical Trial.
Franco V, Perucca E. Franco V, et al. Drugs. 2019 Sep;79(13):1435-1454. doi: 10.1007/s40265-019-01171-4. Drugs. 2019. PMID: 31372958 Review.
Martin-Santos R, Crippa JA, Batalla A, Bhattacharyya S, Atakan Z, Borgwardt S, Allen P, Seal M, Langohr K, Farré M, Zuardi AW, McGuire PK. Martin-Santos R, et al. Curr Pharm Des. 2012;18(32):4966-79. doi: 10.2174/138161212802884780. Curr Pharm Des. 2012. PMID: 22716148 Review.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch-Ernst KI, Maciuk A, Mangelsdorf I, McArdle HJ, Naska A, Pelaez C, Pentieva K, Siani A, Thies F, Tsabouri S, Vinceti M, Cubadda F, Frenzel T, Heinonen M, Marchelli R, Neuhäuser-Berthold M, Poulsen M, Prieto Maradona M, Schlatter JR, Trezza V, van Loveren H, Albert O, Dumas C, Germini A, Gelbmann W, Kass G, Kouloura E, Noriega Fernandez E, Rossi A, Knutsen HK. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), et al. EFSA J. 2022 Jun 7;20(6):e07322. doi: 10.2903/j.efsa.2022.7322. eCollection 2022 Jun. EFSA J. 2022. PMID: 35686177 Free PMC article.
Kirkland AE, Fadus MC, Gruber SA, Gray KM, Wilens TE, Squeglia LM. Kirkland AE, et al. Psychiatry Res. 2022 Feb;308:114347. doi: 10.1016/j.psychres.2021.114347. Epub 2021 Dec 20. Psychiatry Res. 2022. PMID: 34952255 Review.
Connor JP, Stjepanović D, Budney AJ, Le Foll B, Hall WD. Connor JP, et al. Addiction. 2022 Jul;117(7):2075-2095. doi: 10.1111/add.15743. Epub 2022 Jan 10. Addiction. 2022. PMID: 34791767 Free PMC article. Review.
Martin EL, Strickland JC, Schlienz NJ, Munson J, Jackson H, Bonn-Miller MO, Vandrey R. Martin EL, et al. Front Psychiatry. 2021 Sep 9;12:729800. doi: 10.3389/fpsyt.2021.729800. eCollection 2021. Front Psychiatry. 2021. PMID: 34566726 Free PMC article.
Morel A, Lebard P, Dereux A, Azuar J, Questel F, Bellivier F, Marie-Claire C, Fatséas M, Vorspan F, Bloch V. Morel A, et al. Front Psychiatry. 2021 Feb 22;12:565617. doi: 10.3389/fpsyt.2021.565617. eCollection 2021. Front Psychiatry. 2021. PMID: 33692705 Free PMC article. Review.