Can You Take CBD Oil With Cymbalta


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There is little research into the interaction between Cymbalta and cannabis, but there may be one if the two are used together. Can CBD oil be taken with Cymbalta? Here's the general view and exceptions in which a doctor can prescribe both. Plus what each does and the side effects. Can You Take CBD Oil With Cymbalta? Drug interaction is defined as the changes in a drug’s effects due to recent or concurrent use of another drug or drugs (drug-drug interactions), ingestion of

Should You Use Marijuana If You Take Cymbalta?

Cymbalta is a prescription medication used to soothe several medical conditions, such as anxiety, depression and chronic pain. Many of these symptoms are among the approved uses for medical marijuana in legalized states.

While a sizable amount of research explores cannabis’ connection with psychiatric disorders, there’s little that examines antidepressants like Cymbalta’s interaction with marijuana. Some sources suggest that Cymbalta (duloxetine) has a moderate drug-drug interaction with cannabis, potentially interfering with its metabolization by the liver.

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What Is Cymbalta?

Cymbalta — generically called duloxetine —‚ is one of the selective serotonin-norepinephrine reuptake inhibitors (SSNRIs) that increases the levels of serotonin and norepinephrine in the brain. These chemicals influence mood and pain sensations, and taking Cymbalta helps regulate them when their levels are imbalanced.

Side effects of Cymbalta range in severity and include:

Uses and How It Works

SNRIs are a newer class of antidepressants that have shown a more promising ability to regulate mood without the traditional adverse effects of SSRIs like Prozac. Medications like Cymbalta work by modulating the neurotransmitters in the brain that communicate information between brain cells. By preventing the reuptake of serotonin and norepinephrine in the brain, Cymbalta can lift patients out of depression and soothe experiences of pain.

Potential Benefits and Risks of Mixing Cannabis and Cymbalta

Potential Benefits

We do not yet know if cannabis interacts with Cymbalta. Current research implicates marijuana as a promising aid to treat various conditions, including several disorders doctors prescribe Cymbalta to treat. As such, medical marijuana may offer an alternative for individuals who cannot or choose not to take SNRIs.

Evidence suggests that individuals who regularly use medical marijuana experience less depression. CBD, too, counteracts many of the adverse effects of THC’s psychoactivity, which could worsen anxiety with too high a dose. However, CBD is known to interact with many medications due to its impact on metabolic activity in the liver. Be sure to discuss using cannabis and Cymbalta with your doctor before making any changes to your medication routine.

CBG is another promising cannabinoid that could boost the antidepressant ability of Cymbalta. It works by preventing the reuptake of GABA, which contributes to a sense of peace and calm using a different neural pathway than SNRIs.

Download A Free Guide to Medical Marijuana

Potential Risks

While marijuana use and Cymbalta produce many of the same results, users should exercise caution before taking them simultaneously. Cannabis use with Cymbalta could impair cognitive and motor function, making it more difficult to focus or complete tasks.

Additionally, some of marijuana and Cymbalta’s side effects are similar, which could magnify these experiences if the drugs are taken in tandem. Both cannabis and Cymbalta display central nervous system (CNS) depressant properties, which can dangerously reduce heart rate and breathing when too much is taken.

The Bottom Line

There’s still much to learn about mixing cannabis with Cymbalta or other SRNIs; each person’s body handles drugs differently. Always discuss potential changes to your prescription routine with a medical professional before taking action, as a doctor should be able to answer most questions.

Leafwell’s dedicated team of medical professionals is here to guide you through applying for your MMJ card online.

Can CBD Oil Be Taken With Cymbalta? Here’s What Happens

If you’re asking can CBD oil be taken with Cymbalta, then you’re not alone. The use of CBD in oil, and other forms, has become more prevalent in recent years.

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So, it’s not surprising that those taking Cymbalta are looking to understand its interactions with CBD products.

In this article, we’ve outlined what each does, how they work, and whether CBD oil can be taken with Cymbalta – and if so, when and how. Here’s a summary to give you a brief overview.

Can CBD oil be taken with Cymbalta? In general, CBD oil should not be taken with Cymbalta as it can intensify side effects in relation to cognitive process and motor skills. In severe cases, this can lead to serotonin syndrome and liver failure. Some see most side effects as moderate, and doctors can prescribe both.

With that brief takeaway to give you a clear overview of the answer, it’s important to help you become familiar with both these medications and their side effects.

Only through this will it be easier to grasp why CBD oil can or cannot be taken with Cymbalta.

Cymbalta, CBD, and their side effects

In the lead-up to a more comprehensive answer, we’re going to recap on the significance of both Cymbalta and CBD and discover the similarities in which each operates and how both affect the body.


Cymbalta is an SNRI antidepressant. SNRI stands for serotonin-norepinephrine reuptake inhibitor.

What this medication essentially does is block serotonin and norepinephrine from being reabsorbed into your neurons.

Duloxetine is the main active ingredient of Cymbalta.

Cymbalta is used to treat:

  • Major depressive disorder
  • Generalized anxiety disorder
  • Fibromyalgia
  • Pain caused by diabetic neuropathy
  • Osteoarthritis pain
  • Chronic musculoskeletal pain

The common side effects of Cymbalta include:

  • Dry mouth
  • Loss of appetite
  • Dizziness and lightheadedness
  • Nausea
  • Constipation
  • Tiredness and drowsiness
  • Increased sweating
  • Increased blood pressure


CBD stands for cannabidiol. CBD oil is made by extracting CBD from the cannabis plant, then diluting it with a carrier oil like coconut or hemp seed oil.

While CBD is an essential component of the “marijuana plant,” it is derived from the hemp plant. Both plants belong to the same species, but the hemp plant contains 0.3 percent or less THC. Therefore, CBD does not contain THC, which is the psychoactive ingredient in marijuana.

CBD oil is used to treat:

  • Anxiety and depression
  • Insomnia
  • Chronic pain
  • Arthritis or joint pain
  • Epilepsy and other seizure disorders
  • Multiple sclerosis (MS)
  • Lung conditions
  • Sleep disorders
  • Nausea
  • Cancer
  • Allergies or asthma
  • Migraine
  • Cluster and other headaches
  • Post-traumatic stress disorder (PTSD)
  • Parkinson’s disease
  • Alzheimer’s disease

Common side effects of CBD oil include:

  • Dry mouth
  • Diarrhea
  • Weak appetite
  • Drowsiness
  • Fatigue
  • Irritability
  • Liver inflammation
  • Mood changes
  • Decrease in alertness.

Can CBD oil be taken with Cymbalta – the general view

As you can see, both CBD oil and Cymbalta are used for treating similar medical conditions, and equally, they exhibit many similar side effects.

So, essentially, if CBD oil is taken with Cymbalta, the side effects of each other could be magnified, resulting in more severe adverse reactions.

In scientific terms, when both these drugs interact, they can cause problems related to cognitive and motor function.

Cognitive problems include confusion, impaired judgment, concentration problems, and difficulty in thinking. Motor function problems include dizziness and impaired coordination.

Special circumstances

Some consider the side effects of taking CBD oil with Cymbalta – and their interactions – to be moderate.

It is also believed that doctors can recommend CBD oil to be taken with Cymbalta under special circumstances.

This is in situations in which your healthcare provider decides the benefits would likely outweigh the risk.

However, if such a combination is provided, your healthcare provider will need to closely monitor your side effects to ensure you are not at risk of severe adverse reactions.

So, from the perspective of absolute safety, CBD oil should not be taken with Cymbalta, as magnified side effects from taking both together can cause other potentially severe issues too, which we’ll cover below…

What happens if you take CBD oil with Cymbalta?

There are three main negative outcomes of taking CBD oil with Cymbalta. Below are those three outcomes in the order of least to most severe.

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1. Intensified side effects

As we mentioned earlier, the primary negative result of taking CBD oil with Cymbalta is intensified side effects.

In this scenario, 80% of all pharmaceutical products are broken down in the liver. This action is performed by a group of enzymes called Cytochrome P450 (CYP450).

It’s the liver that breaks down both Cymbalta and the cannabinoids like CBD oil and THC.

This naturally means that when CBD oil is taken with Cymbalta, both of these compounds will compete for the enzyme cytochrome P450 (CYP450) in your liver for breaking them down and metabolizing them.

This means that there is a slower rate of metabolizing them. Thus, the effect of each compound is longer and more potent.

The result of this could be exacerbated side effects.

2. Serotonin syndrome

Cymbalta specifically is a serotonin inhibitor that blocks serotonin from being absorbed into your system.

In safe doses, the blockage helps Cymbalta treat the conditions for which it’s been prescribed.

It’s believed that when you add a new drug to your regimen with Cymbalta or when you increase the dose of Cymbalta, it can easily cause “serotonin syndrome.”

Serotonin syndrome is when you have too much serotonin in your system, which could cause a range of side effects.

Some of these side effects include:

  • Agitation or restlessness
  • Confusion
  • Rapid heart rate and high blood pressure
  • Dilated pupils
  • Loss of muscle coordination or twitching muscles
  • Muscle rigidity
  • Heavy sweating
  • Diarrhea

3. Liver failure

This is the final and the most severe risk of taking CBD oil with Cymbalta. Liver failure results in loss of liver functions.

One main reason for liver failure includes overwhelming your liver function by combining medications or supplements like CBD oil and Cymbalta.

Liver failure occurs when your liver cells are damaged and they can no longer perform due to exhaustion.

Symptoms of liver failure include:

  • Nausea
  • Malaise (general sense of feeling unwell)
  • Sleepiness
  • Abdominal swelling
  • Jaundice (yellowing of your skin and eyeballs)
  • Vomiting
  • Disorientation

Exceptions for taking CBD oil with Cymbalta

Some believe that you can replace Cymbalta with CBD oil – and vice versa.

However, this is not scientifically proven and should only be undertaken through consultation with your healthcare provider.

To mitigate against potential problems, some also opt for methods such as:

  • Space out the time between taking CBD oil and Cymbalta (1 – 3 hours generally). This will prevent the drugs from overlapping with the effects of one another.
  • Microdose your cannabis therapy treatment. This is to practice taking the minimal amount of a given substance to achieve your desired results.
  • Slowly increase your cannabis therapy dosage over time. This is where you take your regular dose of Cymbalta and then slowly increase only the intake of CBD oil until the point you feel it’s tolerable or doesn’t reflect intense side effects.
  • Find and consult with a pro-cannabis medical professional. This is the best exception we can recommend. A CBD professional knows exactly how it can work for your body and condition. They may be able to offer dose advice or other strategies to take CBD oil with Cymbalta in such a way as not to intensify the side effects and exacerbate other related problems taking them together.

Again, these are only general guidelines and are NOT meant for official medical advice when taking CBD oil with Cymbalta. Always consult your healthcare provider before making any changes to your treatment.

Final thoughts

We hope this has armed you with what you need to know regarding the question can CBD oil be taken with Cymbalta. There are other ways in which Prescription Hope can assist you too…

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Can You Take CBD Oil With Cymbalta?

Drug interaction is defined as the changes in a drug’s effects due to recent or concurrent use of another drug or drugs (drug-drug interactions), ingestion of food (drug-nutrient interactions), or ingestion of dietary supplements (dietary supplement-drug interactions).

Drug-drug interactions result when two or more drugs react with each other. Such drugs can be from a combination of prescription drugs and/or over-the-counter (OTC) medications. Drugs with a narrow therapeutic range (little difference between therapeutic and lethal dose) are more likely to face incidents of serious drug interactions.

What is CBD oil?

Cannabidiol (CBD) oil is a product that’s derived from cannabis. It’s a type of cannabinoid, which are the chemicals naturally found in marijuana plants. Even though it comes from marijuana plants, CBD doesn’t create a “high” effect or any form of intoxication — that’s caused by another cannabinoid, known as THC. This quality makes CBD an appealing option for those who are looking for relief from pain and other symptoms without the mind-altering effects of cannabis or other side effects related to some pharmaceutical drugs.

CBD oil is made by extracting CBD from the cannabis plant and then diluting it with a carrier oil like coconut oil or hemp seed oil. CBD can be found in a variety of products online and in stores, including dietary supplements, bath soaks, drinks, and food.

It continues to gain momentum in the health and wellness world, with some scientific studies finding that it may ease symptoms of conditions such as chronic pain and anxiety. CBD has shown promise in initial studies as a treatment for both depression and anxiety, and it may cause fewer side effects in some people.

The findings of research may help explain why CBD could be useful in treating depression. They indicate that, in most studies, CBD appears to have a positive interaction with serotonin receptors in the brain. Serotonin impacts a range of functions in the body, including a person’s emotional state and feelings of well-being or happiness. Keeping serotonin levels balanced is often a key therapy for people with depression.

What is Cymbalta?

Cymbalta is a brand of duloxetine, a selective serotonin, and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be unbalanced in people with depression. Cymbalta is used to treat major depressive disorder in adults. It is also used to treat general anxiety disorder in adults and children who are at least 7 years old.

Cymbalta is also used in adults to treat nerve pain caused by diabetes (diabetic neuropathy), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). Cymbalta is also used to treat fibromyalgia (a chronic pain disorder) in adults and children at least 13 years old.

Duloxetine comes as a delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) capsule to take by mouth. When duloxetine is used to treat depression, it is usually taken once or twice a day with or without food.

Can You Take CBD Oil With Cymbalta?

No, using CBD oil and Cymbalta together may increase the risk of side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.

In addition, CBD oil can interfere with the liver enzymes that break down Cymbalta, their interactions may lead to insufficient concentrations of the drug in the body and affect how the medication works. In severe cases, using CBD oil and Cymbalta together can lead to liver failure and or serotonin syndrome which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.

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