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Does CBD Interact With Escitalopram (Lexapro)?

Escitalopram (Lexapro) is an antidepressant of the serotonin reuptake inhibitor (SSRI) class.

It’s used to treat depression, anxiety, and obsessive-compulsive disorder.

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CBD may slow down the metabolism of escitalopram and lead to its excess accumulation in the body , making it more potent but more liable to cause unwanted side effects.

Can CBD and escitalopram be taken together safely?

Table of Contents

Does CBD Interact With Escitalopram (Lexapro)?

CBD (cannabidiol) may interact with escitalopram (Lexapro). There are two ways by which CBD and escitalopram can act:

1. Slowed Elimination (Metabolic Inhibitor)

CBD can slow the metabolism of escitalopram and consequently increase its concentration in circulation.

Metabolic inhibition occurs when two drugs get metabolized by the same enzymes. Hence, they compete against each other for the said enzymes, slowing down the metabolism of one or both drugs.

Escitalopram is metabolized by CYP2C19, CYP2D6, and CYP3A4 enzymes. These same enzymes metabolize CBD as well.

CBD also has the additional feature of inhibiting these enzymes. Therefore, taking escitalopram and CBD together could slow down the metabolism of the former, leading to an unhealthy accumulation of this compound in the body [1].

It could lead to more side effects of escitalopram such as headache, nausea, drowsiness, etc.

There is a possibility that an excess of taking these two drugs together could give rise to serotonin syndrome, a condition where the body has too much amount of serotonin.

2. Increased Effect (Agonistic Interaction)

CBD can interact with escitalopram agonistically as well.

Agonistic interaction happens when two drugs have a similar effect on the body. They work on the same receptors causing the effects in the same direction.

Both escitalopram and CBD act on the central nervous system (CNS). While escitalopram acts by increasing the levels of serotonin, CBD acts by neuromodulation. Although their mechanism of action is different, they both have similar anxiolytic and antidepressant actions when consumed.

If taken together, the actions of these substances could have a synergistic effect. However, this may also cause an exaggeration in the intended effects leading to symptoms such as drowsiness and lethargy.

Other Names For Escitalopram

Escitalopram is sold under many different names. All share the same risk and potential interactions.

Other names for escitalopram (Lexapro) include:

  • Cipralex
  • Jolivel
  • Cilentra
  • Elorpax
  • Nexito
  • Stalopram
  • Senspram

Similar Medications: CBD & Escitalopram (Lexapro)

Escitalopram (Lexapro) is classified as a selective serotonin reuptake inhibitor (SSRIs). CBD and SSRIs all share similar risks for interaction and side effects.

Here’s a list of similar medications that share a similar level of risk when combined with CBD:

  • Citalopram (Cipramil and Celexa)
  • Dapoxetine (Priligy)
  • Fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra, and Oxactin)
  • Fluvoxamine (Faverin)
  • Paroxetine (Seroxat)
  • Sertraline (Lustral)
  • Vortioxetine (Brintellix)

Is It Safe to Take CBD & Escitalopram (Lexapro) Together?

While the risk of interaction with CBD and escitalopram is low, it’s not impossible. The potential side effects from this interaction can be severe, which make it a bad idea to combine these drugs unless you’ve consulted with your prescribing doctor first.

The interaction between CBD and escitalopram is considered moderate.

Is CBD a Viable Alternative to Escitalopram (Lexapro)?

CBD could be a viable alternative to escitalopram (Lexapro), but not if you’re currently using escitalopram.

CBD can help with depression and anxiety and might even help with OCD, but it might not be enough for some people.

If you’re currently using an antidepressant, you have to talk to your doctor about using CBD. Never adjust your dose or add CBD on your own.

CBD may act as an antidepressant as per some studies on animal models [2]. It may possess fast-onset and sustained antidepressant effects through molecular changes in the brain cells and interactions with various neurotransmitters.

Via similar pathways, CBD may also decrease symptoms of anxiety and anxiety disorders [3].

What Is Escitalopram (Lexapro)?

Escitalopram (Lexapro) is an antidepressant of the selective serotonin reuptake inhibitor (SSRIs) family.

It is an FDA-approved prescription drug that’s used as a treatment for major depressive disorder (MDD), generalized anxiety disorder (GAD), and other psychiatric disorders such as obsessive-compulsive disorder (OCD).

Escitalopram Specs:

Drug Name Escitalopram
Trade Names Lexapro, Cipralex, Jolivel, Cilentra, Elorpax, Nexito
Classification Selective Serotonin Reuptake Inhibitor (SSRIs)
CYP Metabolism CYP2C19, CYP2D6, and CYP3A4.
Interaction With CBD Metabolic competitor
Risk of Interaction Moderate

What Does Escitalopram (Lexapro) Do?

Escitalopram (Lexapro) works as an antidepressant and an anxiolytic by stopping the serotonin (5-HT) reuptake in the brain.

Serotonin stabilizes the mood, happiness, and feeling of well-being in the body. Studies have found that the level of serotonin in the brain is lower in people with depression. This action could lead to the effects commonly experienced in depression, such as low mood, lack of interest in previously enjoyable activities, etc.

Escitalopram increases the level of serotonin in the brain by stopping its reuptake into the presynaptic neuron. It binds to the orthosteric or the primary binding site on the serotonin transporter (SERT). SERT is the same site where the endogenous serotonin binds. By binding to the SERT, escitalopram thus prevents the reuptake of serotonin. Escitalopram has almost no affinity at other receptors such as histamine and muscarinic receptors.

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Escitalopram is the S-enantiomer of racemic citalopram. It is nearly 150 times more potent than citalopram’s R-enantiomer and is responsible for most of the citalopram’s activity. Of all the SSRIs, escitalopram has the highest selectivity for the serotonin transporter. It means it has the lowest rates of adverse effects as compared to other drugs of SSRI. It is also more efficacious and has a faster onset compared to other SSRIs.

Escitalopram, like other SSRIs, can cause abnormal bleeding. Patients at risk of bleeding or those receiving other serotonergic drugs need to be highly cautious.

Side Effects of Escitalopram (Lexapro)

The following list includes the most common side effects of escitalopram:

  • Headache
  • Nausea
  • Ejaculation disorder
  • Somnolence
  • Insomnia
  • Dry mouth
  • Constipation
  • Fatigue
  • Diarrhea
  • Indigestion
  • Decreased appetite
  • Vomiting
  • Lethargy
  • Weight gain

Key Takeaways: Is It Safe to Take Escitalopram (Lexapro) With CBD?

CBD carries a moderate risk of interaction with escitalopram by slowing down the metabolism of escitalopram in the body and acting synergistically with its antidepressant effects.

This may increase the potency of escitalopram by increasing its concentration in the body.

Always discuss new supplements with your doctor if you’ve been prescribed any medications, including escitalopram.

In most cases, CBD won’t interact with SSRIs. However, in rare cases, this combination could result in serious side effects.

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The ordinary barracks can accommodate more than 500 people, and now there are only more than 100 soldiers living in it.

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Evil crows all over the sky! Swain did not retreat but advanced, and rushed towards the soldiers of the blue shirt cbd oil and coconut oil army with the evil crows in the sky.

Soldiers, line up and follow me! One hundred centaur archers left the jungle in a mighty manner and ran towards the cbd oil for anxiety direction of the blue shirt army.

Alex said with concern, Xiaoxiao: Don t worry, I will ride the Gale Eagle and I will be at Folkestone Town soon, Now seeing the distress signal, it can you take cbd with lexapro is likely that another can you take cbd with lexapro part of the soldiers escaped and called for help.

The mushroom bomb cloud nine hemp syrup exploded, and three seventh-level soldiers were seriously injured on the spot.

The nails on cbd for anxiety its four claws were sharp and sharp, There is no doubt that it can easily tear a person to shreds.

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Especially if you take refuge in some small lords, you will basically be trusted by the lords as confidants, which is much better than being a thc gummies thief in this remote place, Introduce myself, can you take cbd with lexapro my name is Cornell Falvin, and it s not wrong to say that it is the eldest young master of the City Lord s Mansion.

This chick cbd oil dosage chart really has some strength, Bloom is cbd oil legal in louisiana sighed, not worried about running away.

You don t have htc gummies to wipe out the Huaxia Army, just leave the guy named Swain behind! In this way, I can also have an explanation for Carus.

He found paper and pen and wrote down the plan for the imperial examination, Cornell stayed in the Huaxia Collar for a long time before leaving, can you take cbd with lexapro knowing that the current foundation of the Huaxia Collar has been taken care of by Kang.

Very good, thc gummies very good, Haha laughed, cbd gummies for flying anxiety gummies delicious and Arthur and Arthur finalized the matter of the legal court, very happy.

Kenny Wells smiled kindly when he saw him looking at him, and nodded in response with a smile.

If you look closely, the golden liquid looks a little illusory, and it doesn t seem to be a real liquid, Dao, this name is considered a Give a sustenance to the self who has come can you take cbd with lexapro through, after all, he is still a Chinese in his bones.

I always thought that there cbd oil affiliate programs were no gods in the Eastern Continent and Western Continent, and all the gods Can You Take Cbd With Lexapro came from the Origin Continent.

I will be working in Huaxia Town in cbd oil 350 mg the future, I want to take over the teacher for convenience.

However, Swain had already made a decision in his heart, and he must find an opportunity to do something in the future to make the Lord Lord change and get rid of cannabis gummies the kindness problem, This sentence was shouted out by the commander of the blue shirt best does cbd help anxiety army cbd for anxiety using a grudge, and his thc gummies can you take cbd Can You Take Cbd With Lexapro with lexapro words could be heard clearly in the distance.

Looking jolly green oil cbd gummies at the iron-clad leopard again, there was only a white mark where it was gummies hit.

So he can only surround the Demacian heavy infantry here, but hesitantly does not know what to do.

Stuart s eagle cbd gummies tincture thighs, can you take cbd with lexapro bulk organic cbd full spectrum gummies shoulders, and abdomen have all been cut with long wounds. retreat! The leader can you take cbd with lexapro of the five ordered, and then the five fled into the distance at the same time.

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Lord Lord, hurry up, I cbd gummies products can only deal with one sixth-level fighter, martha stwart cbd gummies and I can t hold on for two! Lux shouted anxiously.

None of them thought cbd gummies real r that the eighth-level eagle-shaped monster was actually domesticated by Huaxia.

In fact, as early as the Yuan Continent period more than 2,000 years ago, Bright Silver was very popular among nobles, In mid-September, the village of Gil contacted again two villages that were willing to can you take cbd with lexapro relocate the whole village to Trucun.

You should have heard what I said just now, Looking at the twelve thieves, he said, From now on, you cheapest cbd oil reddit will be the hard laborers in the territory.

After the cavalry in front collided with the mushroom bomb, the cavalry behind did not have time to stop vital cbd oil their horses and could only choose to slam into it, causing cbd gummies products secondary damage.

This time the two villages are far away from the Huaxia collar, Naturally, it is impossible to complete the migration in just one day as before. When I came to the central can you how many cbd gummies should i take for anxiety take cbd with lexapro square, the first thing I saw was the bustling crowd.

The candidates maxhemp who came to take the test were okay, because they were not familiar with the tavern owner and did not respond much.

The leading black armored warrior confronted the road extremely arrogantly.

Logically speaking, the farmland can cbd gummies cause depression near the territory should be full of busy farmers, Isn t it ten can you Can You Take Cbd With Lexapro take cbd with lexapro thousand gold coins? Young master, I will save up slowly.

If you just observe the fighting situation of one or two people, and infer the cbd gummy canibus gummies candies strength of these two people, most warriors or magicians can do it.

Arthur already knows about the high-level personnel of Huaxia Town, In his opinion, the position of the mayor of Huaxia Town is not in Alutong now.

He also expects to develop the territory with the rewards Can You Take Cbd With Lexapro of the kingdom, The soldiers of the guardian army and the guardian army reserve army are all talented can you take cbd with lexapro in fighting spirit cultivation.

Entering the system space, the six prizes this time are two wooden thc gummy prices boxes, a drawing, an egg, a token, and a medlinePlus cbd oil for anxiety statue.

Arthur s words, especially the word wine bag and rice bag, made the young nobleman angry.

After all, cbd oil extracts the attraction of cbd cream miracles is not small, If the other party doesn t believe it, it s fine, In a territory, can you take cbd with lexapro two places are the most important, the granary and the treasury.

Because of the soldiers summoned by the system, the height of royal cbd gummies the soldiers highest cbd oil in this team turned out to be exactly the same, all 1 9 meters tall.

Swain, can you take cbd with lexapro sale pills I ve always hated you, I thought you were an evil and cruel fellow.

Okay, worthy of being a son cbd gummies near me of the Sen Lan family, a health gummies soldier said, Let s join forces to clean up this pure thc gummies self-deprecating fellow today. wonderful cbd oils It s better, it s not harmful to the village of Truu! can you take cbd with lexapro The eyes of cbd for pain cbd pills the village chief Jill are full of gratitude.

The village chief Jill still accepted the order, The Lord s order, when did you miss it? Although otc pills gummies the village chief of cold press extraction cbd gummies Jill is quite critical of putting aside the construction of the lord s palace again.

With an eagle call, the Gale Eagle descended from the sky and landed beside him.

The camp that Cornell arranged for the Chinese leader is located on the right cbd oil side effects and gummies price then the right side of the city lord s mansion camp, with the Red Rose Territory s camp in the middle, and the Leiqi territory s drops gummies camp on the left of the city lord s mansion camp, Cornell discussed with the people gathered under the city can you take cbd with lexapro and decided to form a coalition to attack the dungeon.

After Lux finished speaking, he answered, Shaking his head, he doesn t think cbd gummies phoenix az Yasuo is the one who chooses to drink cbd gummies after being defeated once, there must be other reasons.

This question is the most suitable, Through this question, you can understand the governance concept and governance ability of each candidate to govern the town, select talents with outstanding ability and suitable for the Chinese leader, and let them serve as the mayor of each town to govern the town.

And it is a whole piece of golden steel rock! Nima, our luck is too bad! He couldn t help but swear. In his opinion, this was not a war, can you take cbd with lexapro but a one-sided massacre! I must let the Chinese leader know the consequences of offending my Eric.

It anxiety gummies cvs s not too late, I plan to dig out this tunnel tonight, said, If everyone is interested, you can come over at night.

On the avenue, except for the twenty fifth-order guards brought by Eric who remained motionless, the other soldiers had already pros and cons of cbd oil for sleep run to the yellow silk grass to surround the three of Lacus.

Rush in and encounter armored soldiers, if you dare to resist, kill them directly, Unfortunately, no matter how fast they gummy ran, how could can you take cbd with lexapro they be faster than cavalry and faster than bow and arrow.

Young man, these two underground cbd gummies fayetteville nc giant elephants are level 7 monsters, can you organics cbd oil side effects deal with them? The snack merchant said as if he had nothing to do with himself: If you can t beat them, run quickly.

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It was decided that night, and can you grow thc from cbd seeds Swain and Swain will lead the team tomorrow morning, and the troops will be led by Folkestone.

The edge of the wilderness area is inaccessible, not to mention ordinary villagers, even thieves will not easily approach, which easily explains why this bright silver Can You Take Cbd With Lexapro mine has only been discovered now. I think these mushroom bombs will give the pursuers a big surprise, especially can you take cbd with lexapro when they are all cavalry! laughed.

Hearing the words of the village chief Jill, he was relieved, Don cbd gummy honolulu cbd gummies staten island t worry, talk slowly, what s going on? asked.

Belle saw her doubts in her eyes and pouted, You don t look down on others, I am a sixth-level magician, much better than you.

Ship doctor, I didn t expect you to be a ninth-level magician! When did you shadow eagles become so rich and rich, and you even sent a ninth-level magician to collect the power of faith, After entering the wilderness, can you take cbd with lexapro he ordered Rek Sai, Follow your orders, my lord.

Side quests: I love war! Mission description: The growth tom selleck cbd oil of a territory is inseparable from the war of iron and full spectrum cbd gummies blood.

Entering the League of Legends element in the system, sure enough, in addition to Hero Summoning, there is another option for the mall in the system.

With 90,000 gold coins in hand, I finally felt relieved, With these 90,000 gold coins in hand, the winner of this war is destined to be the Chinese leader, Just delusional! A thousand soldiers? With a disdainful smile: Pioneer can you take cbd with lexapro knights, charge with me! Centaur archers, long-range support.

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