Read about CBD's therapeutic wellness properties and how it may help manage symptoms of spinal stenosis, including cramping, bowel dysfunction, & back pain. Spinal stenosis is a physical condition often resulting from a failed surgery. Can CBD help alleviate the pain and other symptoms associated with spinal stenosis? Let’s take a look at how its efficacy and safety compare to conventional treatments. A 2018 research revealed that CBD and medical cannabis have analgesic properties helpful in the pain management of patients with failed back surgery syndrome.
Compare the Best CBD Oil for Spinal Stenosis in 2022
Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.
2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
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No other flavors
Approximately 300 drops total
Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.
3. Spruce 2400mg Lab Grade CBD Oil
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No artificial flavoring or colors
No THC-free option
Made from 100% organic and natural ingredients
The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.
4. Avida Full Spectrum CBD Oil Tincture 500mg
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Light Spearmint flavor
No other flavor
Non-THC, Non-detected in drug test
Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.
5. cbdMD CBD Oil Tincture Natural 1500mg
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Various delicious flavors to choose from
cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
Has vegan, organic, and gluten-free ingredients
Free shipping for this particular product within USA
World-class customer service team
cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.
6. CBDistillery THC Free CBD Oil Tinctures
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60-Day Satisfaction Guarantee
Dropper is a bit shaky
Oil extracted from aerial plant parts of US grown industrial hemp
Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.
7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
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No other flavors
A bit pricey compared to competitors
Approximately 100 drops total
This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.
8. cbdMD CBD Oil Tincture Natural 750mg
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Vegan and Gluten free
Does not ship internationally
Has a third-party lab test
Wide variety of CBD strengths and sizes
A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.
9. Hemp Bombs 750mg CBD Oil
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Wide variety of flavors
Incomplete information about the product
Lab test results are complete
Does not ship to all international countries
30-day money-back guarantee
Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.
How We Rank
How CBD May Help With Spinal Stenosis
CBD’s mood-regulating properties work by interacting with the body’s endocannabinoid system (ECS) (1) . The ECS controls vital body functions such as mood, memory, cognition, and immune system.
When the spinal canal or the spaces within the spinal cord narrow, this is defined as spinal stenosis. Narrowing puts pressure on the nerves and causes lower back and neck pain (2) .
It is caused by a spinal cord injury of the central nervous system .
A study revealed that cannabidiol (CBD) has pain-relieving properties that help decrease the back pain of people suffering from failed back surgery syndrome (FBSS) (3) . One of the symptoms of spinal stenosis is lower back pain (4) .
Additionally, a 2020 study suggested that CBD oil may be an effective analgesic and may reduce neuropathic pain (5) , another symptom of spinal stenosis (6) .
Furthermore, depression is closely linked with chronic pain (7) . A study on CBD has shown that it may have antidepressant effects (8) .
Benefits of Using CBD for Spinal Stenosis
Individuals suffering from spinal stenosis are often prescribed pain relievers , such as ibuprofen and opioids , antidepressants , and anti-seizure drugs like gabapentin to deal with the symptoms (9) .
However, harmful side effects are associated with some medications (10) .
Strong pain medication like opioids can cause drowsiness, confusion, nausea, and slowed breathing ( 11) . Physical dependence and addiction are also risks when using opioids .
Meanwhile, CBD has anti-inflammatory properties that may reduce pain, like chronic back pain (12) .
Neuropathic and inflammatory pain are common symptoms associated with spinal stenosis (13) . In addition, a 2017 report has shown that CBD has no risk of substance abuse or addiction ( 14) .
How to Use CBD Oil for Spinal Stenosis
CBD oil can be administered in various ways, including:
- Topicalapplication : CBD topical products like CBD creams, gels, salves, and lotions are applied directly onto the skin for localized pain relief (15) .
- Oral administration : Examples of orally taken CBD products include edibles like gummies and capsules.
- Sublingual administration : A few drops of CBD tinctures or CBD oils are held under the tongue for about 60 seconds before they are swallowed.
- Inhalation method : CBD may be inhaled through vaping, allowing you to feel the effects of CBD quicker as it leads straight into the bloodstream (16) .
However, vaping has been reported to cause health risks such as lung disease (17) .
In addition, the Food and Drug Administration ( FDA ) in the United States does not consider CBD products like CBD oil as medication (18) .
Consult with your doctor for medical advice if you plan to use CBD products for spinal stenosis . They can advise you on what best method of CBD to use.
How to Choose the Best CBD Oil for Spinal Stenosis
Choosing the right CBD product depends on various factors, such as your personal preference, the severity of your condition, and the form of cannabidiol .
There are three types of CBD oil extracts:
- Full-spectrum CBD oil
- Broad-spectrum CBD oil
- CBD isolates
Full-spectrum CBD oil has all the extracts of the cannabis plants , such as flavonoids, terpenes, essential oils, and other cannabinoids . Additionally, full-spectrum CBD oil has a THC concentration of less than 0.3% (19) .
Flavonoids are responsible for the pigment of plants, while terpenes are responsible for the smell.
Broad-spectrum CBD oil is much like full-spectrum. However, broad-spectrum CBD only contains trace amounts of THC or none at all.
Lastly, CBD isolates, typically harvested from Cannabis sativa, are a pure form of cannabidiol ( 20) .
The entourage effect produced by full-spectrum hemp extracts yields more health benefits than pure CBD (21) .
CBD Dosage for Spinal Stenosis
There is no set dosage to administer CBD oil in managing the types of spinal stenosis , including cervical stenosis and lumbar stenosis (22) .
However, a 2018 study has shown that patients suffering from FBSS were given a fixed dose of CBD for their back pain management, resulting in decreased pain (23) .
Low back pain is one leading symptom of spinal stenosis (24) .
How Long Does CBD Take to Help With Spinal Stenosis ?
The administration, dosage, and form can determine how long CBD products can affect your body.
CBD topical treatments like creams , ointments, and edibles take as long as one to two hours before taking effect (25) .
Sublingual administration of CBD oil and tinctures is usually felt within 15 to 45 minutes as it directly enters the bloodstream (26) .
How Long Will CBD Help With Spinal Stenosis ?
No studies have determined how long CBD oil takes to help people suffering from spinal stenosis . However, the duration generally depends on the dosage and the frequency of consumption of CBD.
CBD can typically stay in your system for two to five days or a few weeks (27) .
Risks and Side Effects of Using CBD for Spinal Stenosis
Currently, there is no study on CBD’s risk and side effects when used to treat spinal stenosis .
Meanwhile, the World Health Organization (WHO) states that CBD, in general, has a good safety profile, is tolerated well by the body, and does not pose any risk of abuse (28) .
Still, there are minor side effects associated with CBD, such as (29) :
- Dry mouth
- Reduced appetite
Consult with your doctor before trying any CBD product . They may provide information about potential drug-to-drug interactions.
Legality of CBD
According to the Farm Bill in 2018, hemp-based CBD oil i s considered legal in the federal United States (30) .
However, marijuana-based CBD products which contain more than 0.3% delta-9- tetrahydrocannabinol ( THC ) remain illegal in several states (31) .
It is important to check your CBD product ’s THC levels and your state laws to verify that your product can be legally used.
How can CBD help with spinal stenosis?
In a 2018 study, results showed that CBD may have pain-relieving properties that can help decrease the back pain level of individuals with failed back surgery syndrome (FBSS) (32) . Chronic lower back pain is one main symptoms of spinal stenosi s ( 33) .
Furthermore, depression is closely linked with chronic pain (34) . A study on CBD has shown that the compound may have antidepressant effects (35) .
What evidence or research exists to say that CBD helps with spinal stenosis?
In a 2020 study, it was suggested that CBD oil may also be used as an analgesic to treat neuropathy , which is a chronic pain condition from damaged nerves (36) .
Neuropathic pain is another symptom of spinal stenosis (37) .
Is there any evidence that CBD can make spinal stenosis worse?
According to the World Health Organization (WHO), CBD is safe, well-tolerated by the body (38) , and non-addictive (39) .
However, CBD can cause minor side effects , such as lightheadedness, drowsiness, diarrhea, and nausea (40) .
CBD may also interact with other drugs, such as anti-seizure medications for spinal stenoses (41) .
Consult with your doctor before taking CBD products with any of these medications.
Will CBD interact with any current medication I may be taking for spinal stenosis?
CBD is generally safe for humans if used and administered correctly. It does not have any harmful or adverse effects (42) .
However, CBD may cause side effects when taken with certain prescription medications for spinal stenosis, like antidepressants (43) . These side effects may include:
- Dry mouth
Talk to your doctor if you are considering using CBD products along with antidepressants or any other prescription drugs.
Are there other treatments I should consider alongside CBD to help with spinal stenosis?
Conventional treatments for spinal stenosis vary, depending on the severity of symptoms.
A doctor can prescribe pharmaceutical medication, such as pain killers, opioids , anti-seizure drugs , and antidepressants (44) .
Physical therapy is also recommended to improve an individual’s balance and reduce muscle weakness .
Contact sports or any activity that may put too much stress on your spine should also be avoided (45) .
CBD oil may be another treatment option for pain management for spinal stenosis symptoms such as back and neck pain (46) .
There are CBD oil brands that are non- GMO and contain zero pesticides that can be used as topical treatments or tinctures .
Can I fail a drug test if I use CBD for spinal stenosis?
CBD is legal in the United States as long as it contains less than 0.3% THC (47) . However, if taken over time, TCH may accumulate in your bloodstream and may lead to a positive drug test (48) .
What is the dosage for spinal stenosis?
There is no current dosage for CBD oil to treat symptoms of spinal stenosis . However, your diet, weight, and age may determine the effects of CBD on your body (49) .
Consult with a medical professional for a recommendation on the right CBD dosage before using any CBD products for spinal stenosis .
Is CBD Legal?
Hemp-based CBD, like CBD oil , is legal across the United States, according to the 2018 Farm Bill (50) .
However, CBD products with more than 0.3% TCH (delta-9- tetrahydrocannabinol) are still illegal in many states in the US (51) .
For more information on CBD and a particular medical condition, consult your doctor or research through ebooks identified by their DOI (digital object identifier) number.
Can CBD Oil Help with Spinal Stenosis Pain?
CBD has potent anti-inflammatory properties, indicating potential benefits for the symptom control of spinal stenosis, also known as spinal injury.
Spinal stenosis refers to a spine issue associated with high inflammation markers. The discomfort is also followed by nerve pain, further deteriorating the quality of life of many patients. People with spinal stenosis often rely on potent prescription medications — putting themselves at a high risk of dependence and severe withdrawals.
Being unable to rest and function properly throughout the day, individuals suffering from spinal injuries turn to natural remedies for relief.
CBD is touted by the medical community to reduce inflammation and mitigate pain signaling to the brain. These qualities put it high on the list of potential natural alternatives to treating spinal stenosis.
Read this article to find out if CBD can help you with symptom control.
Does CBD Oil Help with Spinal Stenosis Pain?
Some studies suggest that CBD oil could help many spinal stenosis symptoms. In a study published in the Journal of Pain Research in 2018, the research team examined the link between cannabinoids and spinal cord stimulation in patients with spinal stenosis from a failed back surgery.
The Italian study analyzed the situation of 11 patients diagnosed with neuropathic pain after their surgery. All participants discontinued other treatments in favor of a cannabinoid-based solution. They were taking a predetermined dose of THC/CBD, which they could adjust to their response. At the end of the study, the patients reported significant improvement in pain while recovering from surgery compared to the beginning of the trial .
Several spinal disorders, including spinal cord injury, spinal stenosis, and radiculopathy (pinched nerve) due to herniated discs, are common triggers of nerve pain.
A research paper published in 2020 in C current Pharmaceutical Biotechnology analyzed the efficacy of CBD oil in managing neuropathic pain in 29 participants with peripheral neuropathy.
The group that received CBD reported that their severe pain and cold, itchy sensations had been diminished significantly. They also didn’t report any adverse effects. The researchers concluded that transdermal use of CBD oil helps considerably improve pain and other types of discomfort experienced by patients with peripheral neuropathy .
CBD for Other Spinal Stenosis-Related Symptoms
Spinal stenosis — and chronic back pain in general — is often accompanied by anxiety. A study posted in the Journal of Psychopharmacology in 2011 evaluated the effects of CBD on social anxiety disorder (SAD). The authors found that patients with SAD who used a high dose of CBD reported substantial improvements . CBD can help manage anxiety disorders by acting on serotonin and GABA receptors on top of improving endocannabinoid signaling in the brain .
Another study on CBD and anxiety — published in The Permanente Journal — investigated the efficacy of CBD on sleeping disorders and anxiety . The final sample examined 72 adults, 47 of whom reported anxiety as their primary health problem. The other 25 volunteers pointed to sleep deprivation as the main issue.
Almost 80% of participants experienced significant relief from anxiety within the first month. Sleep scores improved in over 66% of the tested subjects . Individuals with spinal stenosis struggle with anxiety and insomnia; when combined, they can take a serious toll on their overall well-being.
How CBD Helps to Alleviate Symptoms of Spinal Stenosis
CBD’s potential in controlling the symptoms of spinal stenosis is largely attributed to its interaction with endocannabinoid receptors, serotonin receptors, and TRPV-1 vanilloid receptors.
In a 2014 study published in the British Journal of Pharmacology , CBD was found to inhibit chemotherapy-induced neuropathic pain. The researchers discovered that the analgesic and anti-inflammatory effects of CBD could be produced partly by its interaction with the 5-HT1A (serotonin) receptor .
Interestingly, this interaction can also reduce anxiety levels, a more stable mood, and better emotional control.
A 2019 study further confirmed these findings in a mice model, showing that CBD decreased anxiety-like behavior and normalized serotonin activity .
CBD can also mitigate pain signals by engaging with TRPV-1 vanilloid receptors, which are the same receptors that respond to the terpenes in vanilla beans; these essential oils are responsible for the pain-dampening properties of vanilla — the reason why it has been widely used in folk medicine.
In a 2012 study published in Pharmaceuticals , the authors found a strong link between TRPV1 cells and autoimmune diseases and inflammation. This fuels the hypothesis that CBD’s impact on TRPV1 receptors helps mitigate pain signals and curb inflammation .
Last but not least, CBD can help the body level its endocannabinoid deficiencies. Not only does it signal the endocannabinoid system to produce its own endocannabinoids, but it also acts as the inhibitor of enzymes that break them down. Higher levels of endocannabinoids such as anandamide have been associated with a higher pain threshold and better stress response.
How to Use CBD Oil for Spinal Stenosis
CBD comes in many different forms. The most common format is CBD oil , which contains a CBD-rich hemp extract that is infused into a carrier oil.
CBD oil is taken sublingually (under the tongue). You need to use a dropper attached to the bottle of your oil to measure out the desired amount — then transfer it beneath the tongue and hold it in your mouth for up to 60 seconds.
From there, CBD, along with other phytonutrients, will travel to your bloodstream using the tiny capillaries under the tongue. Sublingual absorption improves the bioavailability of CBD and speeds up the onset of its calming and relaxing effects. Bioavailability refers to the amount of CBD that ends up in your bloodstream after ingestion.
The leftover amount of CBD oil is swallowed and processed by the digestive system.
CBD oil combines relatively high bioavailability with dosage precision, which is why many people use it as their go-to way to supplement cannabidiol.
The best type of CBD oil for spinal stenosis is the ful l -spectrum one because it contains all the valuable compounds from hemp; CBD and other cannabinoids, terpenes, and flavonoids work synergistically to create the entourage effect — enhancing the therapeutic efficacy of the product.
However, the problem with full-spectrum CBD oil is that it carries a strong earthy flavor, which may not appeal to many users. If you have a sensitive palate, you may want to consider the following alternatives:
CBD Cream for Spinal Stenosis
CBD cream is a decent option for spinal stenosis if you want to add a targeted approach to your treatment. While products like CBD oil or capsules will help reduce inflammation and dampen painful sensations from within, CBD topicals, such as creams, ointments, and gels, offer localized pain relief.
When you apply CBD directly to the skin, it interacts with the CB2 receptors of the skin’s endocannabinoid system. This results in an anti-inflammatory response because CBD acts on adenosine receptors, which block the inflammatory proteins known as cytokines.
Using CBD topically may help you reduce back pain, swelling, redness, and pain of inflammation.
CBD Gummies for Spinal Stenosis
If you dislike the taste of CBD oil, you may try out CBD gummies for spinal stenosis. They are available in different flavors, potencies, shapes, and formulas and resemble regular gummy bears. Gummies offer a fixed dose of CBD per serving and deliver it to your system through the gastrointestinal tract. This method of administration has some significant advantages, but it also has one drawback.
Speaking of the positives, a predetermined amount of CBD in each gummy makes it easier to calculate the dosage. For example, if you benefit from 50 mg of CBD per day and your gummies have 25 mg each, you need to take two gummies to match your dosage.
Once CBD enters the GI tract, it is metabolized by the liver and then gradually released into the bloodstream, ensuring longer-lasting effects (up to 10 hours).
That being said, the effects of oral CBD products have a delayed onset. This phenomenon is known as the first-pass metabolism; it’s also why CBD gummies offer lower bioavailability than oils (around 20%).
CBD Dosage for Degenerative Disc Disease
The CBD space remains unregulated, so there are no dosage guidelines or standard dosage charts for specific conditions, including spinal stenosis pain and other symptoms.
A review of studies assessing CBD dosages in clinical populations concluded that an optimal dose could vary from 1 mg to 50 mg per 10 kg of bodyweight depending on the user’s metabolism, weight, the severity of symptoms, unique body chemistry, and gender.
It’s generally recommended to start with a low dose such as 5–10 mg of CBD and gradually increase the amount until you find a dose that gives you the best results without making you feel dizzy or lethargic.
To learn more about CBD Dosage, head over to this post for a general guideline.
What Is Spinal Stenosis?
Spinal stenosis is a medical name to describe a narrowing of the spaces within the spine; it’s also known as the foramina . This condition reduces the space for the nerves to travel, which can happen in the spinal canal or within the intervertebral foramina.
The spinal cord compression or a spinal nerve can cause tingling, pain, numbness, or weakness. The symptoms can vary depending on the time and the severity of narrowing over time. The location of the issue matters too.
Types of Spinal Stenosis
Spinal stenosis has two main types. The diagnosis depends on the condition’s location; it’s also possible to have both forms of spinal stenosis at the same time.
This type of spinal stenosis occurs when the narrowing affects the neck area of the spine. People with spinal stenosis have spinal cords with less space to travel, which may cause them to compress. The contraction could result in dysfunction and pain anywhere beneath the compressed area.
The symptoms of cervical stenosis include:
- Pain in the neck
- Problems with movements and balance
- Weakness or tingling in an arm, hand, leg, or foot
- Bladder or bowel dysfunction (severe cases)
Patients with lumbar stenosis have the narrowing of the spine at the lower back. Also known as foraminal stenosis, this is the most common type of spinal stenosis:
You may have lumbar stenosis if you experience the following symptoms:
- Back pain
- Cramping in 1 or both legs when walking
- Weakness, numbness, and tingling in a foot or leg
Conventional Spinal Stenosis Treatments & Their Side Effects
Doctors usually diagnose spinal stenosis via tests such as MRI scan, X-ray, or CT myelogram
Treatments for spinal stenosis depend on the location of the condition and the severity of symptoms. A physician may prescribe conventional painkillers, including:
- Anti-seizure drugs like gabapentin or pregabalin
- Non-steroidal anti-inflammatory drugs (NSAID)
- Opioids such as oxycodone or hydrocodone
- Tricyclic antidepressants such as amitriptyline
However, the above treatments come with a risk of dangerous side effects, such as liver damage, kidney failure, weight gain, hormonal imbalances, autoimmune diseases, nausea, and vomiting — not to mention the high potential for dependence and withdrawals when it comes to opioids.
Patients with spinal stenosis tend to become less active physically over time due to the pain experienced when moving. However, this can only cause muscle weakness to deteriorate. Therefore, physical therapy is often recommended as the go-to treatment to improve balance and regain strength and endurance.
Other possible spinal stenosis treatments include:
- Decompression: People with spinal stenosis can ask their doctor about this procedure. Decompression involves removing compressed ligaments from the back of the spine. The process is known as image-guided lumbar decompression and doesn’t require general anesthesia.
- Steroid injections: corticosteroids could alleviate inflammation at the site of the stenosis, dampening pain. Patients can only take a handful of injections annually due to the side effects associated with frequent use, such as weakened bones and connective tissues.
- Surgery: it is performed as a last resort and aims to relieve pressure on the spinal cord or nerve roots. This can be achieved by creating greater space in the spinal canal. Surgical procedures include laminoplasty, laminectomy, and laminotomy.
There are also clinical studies involving the use of stem cells to treat degenerative disc disease. Researchers are also testing several genomic medications.
Summarizing the Potential Benefits of CBD Oil for Spinal Stenosis
Medical researchers are fueling more resources into studies on CBD’s effects on spinal stenosis and other forms of spinal injury. A growing body of evidence suggests that CBD oil can help manage several symptoms related to spinal stenosis, including inflammation, nerve pain, anxiety, and sleep deprivation.
The best part about using CBD for spinal stenosis is that its benefits aren’t accompanied by dangerous side effects, unlike most pharmaceutical medications. CBD is safe and well-tolerated, even in doses as high as 1,500 mg per day.
Research so far suggests that the best approach to treating spinal stenosis with CBD is the combination of a sublingual and topical product. Take CBD oil (or gummies) for general supplementation, and apply topicals directly on the site of the pain to relieve localized discomfort by activating the CB2 receptors with CBD.
- Mondello, E., Quattrone, D., Cardia, L., Bova, G., Mallamace, R., Barbagallo, A. A., Mondello, C., Mannucci, C., Di Pietro, M., Arcoraci, V., & Calapai, G. (2018). Cannabinoids and spinal cord stimulation for the treatment of failed back surgery syndrome refractory pain. Journal of pain research , 11 , 1761–1767. 
- Xu, D. H., Cullen, B. D., Tang, M., & Fang, Y. (2020). The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities. Current pharmaceutical biotechnology , 21 (5), 390–402. 
- Crippa, J. A., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., Simões, M. V., Bhattacharyya, S., Fusar-Poli, P., Atakan, Z., Santos Filho, A., Freitas-Ferrari, M. C., McGuire, P. K., Zuardi, A. W., Busatto, G. F., & Hallak, J. E. (2011). Neural basis of cannabidiol (CBD) anxiolytic effects in generalized social anxiety disorder: a preliminary report. Journal of psychopharmacology (Oxford, England) , 25 (1), 121–130.
- Linge, R., Jiménez-Sánchez, L., Campa, L., Pilar-Cuéllar, F., Vidal, R., Pazos, A., Adell, A., & Díaz, Á. (2016). Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors. Neuropharmacology , 103 , 16–26.
- Pretzsch, C. M., Freyberg, J., Voinescu, B., Lythgoe, D., Horder, J., Mendez, M. A., Wichers, R., Ajram, L., Ivin, G., Heasman, M., Edden, R., Williams, S., Murphy, D., Daly, E., & McAlonan, G. M. (2019). Effects of cannabidiol on brain excitation and inhibition systems; a randomized placebo-controlled single-dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology , 44 (8), 1398–1405. 
- Leweke, F. M., Piomelli, D., Pahlisch, F., Muhl, D., Gerth, C. W., Hoyer, C., Klosterkötter, J., Hellmich, M., & Koethe, D. (2012). Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Translational psychiatry , 2 (3), e94.
- Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente journal , 23 , 18–041. 
- Ward, S. J., McAllister, S. D., Kawamura, R., Murase, R., Neelakantan, H., & Walker, E. A. (2014). Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy. British journal of pharmacology , 171 (3), 636–645.
- De Gregorio, D., McLaughlin, R. J., Posa, L., Ochoa-Sanchez, R., Enns, J., Lopez-Canul, M., Aboud, M., Maione, S., Comai, S., & Gobbi, G. (2019). Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. Pain , 160 (1), 136–150.
- Tsuji, F., & Aono, H. (2012). Role of transient receptor potential vanilloid 1 in inflammation and autoimmune diseases. Pharmaceuticals (Basel, Switzerland) , 5 (8), 837–852.
Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.
CBD Oil for Spinal Stenosis – August 2022
Doctors prescribe over-the-counter pain relievers , such as ibuprofen , antidepressants (like amitriptyline) , anti-seizure drugs, and opioids for spinal stenosis [5 ] . However, these medications may have harmful side effects .
Antidepressants may cause dry mouth, difficulty urinating, constipation, blurred vision, and lowered blood pressure . It may also cause palpitations, weight gain, anorexia, dizziness, insomnia, headaches, and nervousness in some people [6 ] .
Meanwhile, anti-seizure medications may lead to the induction of suicidal thoughts or actions and the worsening of depression. Some of these drugs may also cause severe blood disorders and skin reactions, development of kidney stones, and liver injury [7 ] .
Opioids, the most potent pain-relieving medications, also come with several side effects, such as dizziness, constipation, drowsiness, and hallucinations. Some people may also experience lowered heart rate, decreased blood pressure, nausea, sexual dysfunction, and itching unrelated to allergies—not to mention, dependence and addiction [8 ] .
CBD may have properties useful in treating symptoms associated with spinal stenosis.
CBD for Back Pain
Back pain is one of the symptoms associated with spinal stenosis [9 ] .
A study archived in the Journal of Pain Research examined the effects of CBD and tetrahydrocannabinol ( THC ) on 11 patients with failed back surgery syndrome (FBSS) [10 ] .
The FBSS patients reported moderate to severe chronic pain and persistent low back pain .
The participants received spinal cord stimulation (SCS) treatment combined with CBD and THC for 12 months. The researchers observed that the test subjects’ pain perception decreased significantly.
The authors suggested that the cannabinoids CBD and THC might have analgesic effects. These properties might be useful in treating chronic refractory pain (hard-to-control pain) experienced by FBSS patients.
Cannabinoids are substances that help the endocannabinoid system (ECS) maintain natural harmony in the body [11 ] . They may come from the body, made in laboratories, or extracted from the Cannabis sativa plant, such as CBD and THC.
Compared with THC, CBD does not have psychoactive effects .
A review in the journal Therapeutics and Clinical Risk Management outlined the analgesic effects of cannabinoids, such as CBD. The researchers discussed the ability of these cannabinoids to manage pain that is difficult to treat [12 ] .
The authors also noted that these cannabinoids demonstrated other benefits, like antiemetic (vomit-preventing), neuroprotective, antioxidant, and proapoptotic properties.
Proapoptotic substances promote apoptosis, the process of programmed cell death, which eliminates unwanted cells (i.e. cancer) in the body [13 ] .
CBD for Neuropathic Pain
Several spinal disorders, such as spinal stenosis, spinal cord injury, and radiculopathy (pinched nerve) due to herniated discs , are common causes of neuropathic pain [14 ] .
Research conducted in 2020 and documented in Current Pharmaceutical Biotechnology investigated the efficacy of CBD oil in managing neuropathic pain in 29 patients with peripheral neuropathy [15 ] .
The participants who received CBD reported that their severe pain and cold, itchy sensations reduced significantly. They also did not experience adverse effects.
The authors concluded that CBD oil’s transdermal application might help with significant improvement in pain and other disturbing sensations in peripheral neuropathy patients.
In multiple sclerosis , chronic neuropathic pain is a symptom detrimental to patients’ quality of life [16 ] .
Authors of a study in the journal Frontiers in Neurology reported that CBD might help improve the mobility of people with multiple sclerosis [17 ] .
They also added that CBD had properties that reduced spasticity (muscle tightening), pain, inflammation, depression, and fatigue in people with multiple sclerosis.
CBD for Anxiety and Depression
According to Harvard Medical School, chronic back pain is integrally connected to an individual’s state of mind. Limited movement may result in psychological distress, which can worsen lower back pain [18 ] .
Emotions, like anxiety, have a significant influence on chronic back pain. Emotional control may also become more difficult [19 ] .
A 2017 study documented in The Spine Journal found that chronic low back pain increases the risk of developing anxiety and depression symptoms [20 ] .
However, the authors could not determine whether these symptoms cause back pain or the pain-related condition causes anxiety and depression symptoms.
A 2014 review found in CNS and Neurological Disorders Drug Targets reported that CBD had anxiolytic (anxiety-reducing) and antidepressant effects on several animal models [21 ] .
The literature review revealed that these properties might be caused by the interaction between CBD and the 5-HT1A neurotransmitter, a serotonin receptor subtype.
Serotonin is a vital hormone that helps stabilize mood, happiness, and feelings of well-being. Low se rotonin levels are associated with several behavioral and emotional disorders, such as depression and anxiety [22 ] .
A non-systematic literature review in the journal Frontiers in Immunology outlined CBD’s anxiolytic, neuroprotective, and antipsychotic properties [23 ] .
The researchers also concluded that CBD might be promising in treating depression, sleep disorders, post-traumatic stress, epilepsy, and substance abuse.
How CBD Oil Works to Alleviate Symptoms of Spinal Stenosis
CBD’s purported ability to target serotonin receptors may help with the pain and anxiolytic symptoms associated with spinal stenosis.
A 2014 study documented in the British Journal of Pharmacology stated that CBD inhibited chemotherapy medication-induced neuropathic pain [24 ] .
The researchers discovered that the substance produced analgesic and anti-inflammatory properties because of its interaction with the 5-HT1A (serotonin) receptor.
A 2019 study archived in the journal Pain showed that CBD decreased anxiety-like behavior and normalized 5-HT1A activity in a mouse model of neuropathic pain [25 ] .
The rodent test subjects were treated with CBD for one week. The authors also reported that CBD reduced mechanical allodynia.
Mechanical allodynia is a nerve-related condition characterized by pain from supposedly non-painful stimuli, such as a light touch to the skin [26 ] .
The Pros and Cons of CBD Oil for Spinal Stenosis
- Previously cited research studies in humans and animals showed that CBD might be promising in alleviating spinal stenosis pain symptoms .
- Compared with conventional medications for spinal stenosis, CBD is well-tolerated and has an excellent safety profile, as found by the World Health Organization (WHO) [27 ] .
- According to the National Institute on Drug Abuse, CBD seems to be a safe drug with no addictive effects [28 ] .
- In states that allow CBD use, CBD products may be purchased without a prescription.
- More clinical trials , animal research, and human studies should be conducted to assess CBD’s effects on spinal column conditions, such as spinal stenosis.
- CBD may still cause side effects, including nausea, fatigue, and irritability [29 ] .
- Spinal stenosis medications, such as antidepressants and antiepileptics, may have drug interactions with CBD that could potentially be adverse [30 ] . Thus, CBD should not be combined with these medications.
- The United States Food and Drug Administration (US FDA) does not support CBD use for medical conditions other than epilepsy [31 ] .
How CBD Oil Compares to Alternative Treatments for Spinal Stenosis
Individuals with spinal stenosis may explore alternative treatments for their health conditions .
A 2016 case study used massage therapy to relieve chronic low back pain in a patient with spinal stenosis, osteoarthritis, scoliosis, and disc degeneration -related disease [32 ] .
The 61-year-old male exhibited improvement in 9 out of 10 measurements of self-reported pain and activities of daily living.
Dramatic differences were seen in the test subject’s post-massage therapy, such as improvements in the ability to walk and changes in degrees of pain.
According to the patient, he was able to decrease his pain medication. He was also able to ride his bicycle for the first time in years.
Researchers concluded that massage therapy is a promising treatment accessible and cost-efficient compared with other invasive therapies. They also recommend that this approach should be used as an adjunct therapy to regular medical care.
Another alternative remedy for spinal stenosis is chiropractic treatment [33 ] .
A literature review in the Journal of Chiropractic Medicine investigated the effects of chiropractic treatment on lumbar spinal stenosis . The researchers concluded that the alternative practice might have beneficial effects on the spine-related condition [34 ] .
Still, they recognize that the research is very limited and that further clinical investigations should be conducted on chiropractic medicine as an alternative treatment for the different types of spinal stenosis.
Chiropractic treatment involves trained specialists using a small instrument or their hands to apply controlled and sudden forces to the spinal joint. This procedure aims to improve spinal motion and the body’s physical function [35 ] .
Like massage therapy, CBD may help relieve pain due to its analgesic properties [36 ] .
Meanwhile, compared to chiropractic treatment, CBD may also help improve the mobility of people with some conditions that affect the central nervous system , like multiple sclerosis [37 ] .
Surgeries and Future Treatments
Individuals who do not experience pain relief from conventional spinal stenosis treatments, such as physical therapy and pain medications, should consider surgery [38 ] .
Surgery relieves spinal cord and nerve root pressure by creating more space in the spinal canal .
Still, spinal stenosis surgery may have risks, including infection, bleeding, nerve injury, and stiffness [39 ] .
The latest treatment being developed for spinal stenosis is the use of stem cells to treat degenerative spinal diseases. This approach is called regenerative medicine [40 ] .
Stem cells have great potential to develop into various body cell types. They are seen as a repair system for the body [41 ] .
How to Choose the Right CBD for Spinal Stenosis
A 2020 review of scientific research showed that CBD and THC had analgesic properties useful in managing chronic neuropathic pain [42 ] .
However, medical marijuana use is not legal in all US states [43 ] .
Full-spectrum CBD products contain legal amounts of THC. This CBD type also uses all the components of the cannabis plant , such as terpenes, flavonoids, essential oils, and fatty acids.
It is believed that all these ingredients work together to derive the full therapeutic benefits of the Cannabis sativa plant in a process known as the entourage effect. Thus, full-spectrum CBD oils may be beneficial for treating spinal stenosis.
However, individuals should note that some drug tests may still detect the THC composition of full-spectrum products.
A THC-free CBD type that contains all the other ingredients of the cannabis plant may also be an option. This type is called broad-spectrum CBD.
Another option is pure, isolated cannabidiol, known as CBD isolates.
Buyers should refer to the following guidelines to ensure that CBD products are of high-quality :
- Check with the local government if CBD purchase and use are legal in the area.
- Ensure that the products are high-quality, non-GMO, and organic hemp-derived CBD.
- Read online reviews, especially when the CBD manufacturer has no brick-and-mortar store. These comments and feedback offer genuine and often useful insights from real customers. Always ensure that the government has authorized the store to sell CBD products.
- CBD products have different extraction methods. Learning about the extraction process of a CBD product is essential. According to research, the US FDA in pharmaceutical manufacturing acknowledges that CO2 extraction is safe [44 ] .
- Search for reports, such as the certificate of analysis of CBD products. These documents verify the validity of the product’s claims and potency. Credible CBD companies employ third-party, independent laboratories to examine their products.
- Ensure that the products are legitimate. Researchers reviewed 84 CBD products bought online and found that 26% contained less CBD than labeled, while 43% contained more CBD than what was declared on the product label [45 ] . They also discovered that 21% contained THC amounts that were enough to get children high.
- Consult with a healthcare professional before using any CBD products.
CBD Dosage for Spinal Stenosis
CBD remains to be unregulated. Hence, there is no standard dosage chart for cannabidiol use in treating spinal stenosis nerve pain and other symptoms.
For CBD dosing, people are recommended to“start low and go slow.” Initial dosage may be small amounts and, if no harmful side effects are observed, the dose may be increased gradually.
Individuals are encouraged to document their reactions to CBD during treatment. Recording their experiences with CBD in a journal may help.
Always first consult with a doctor before taking any CBD product.
How to Take CBD for Spinal Stenosis
Researchers of a study found that the transdermal application of CBD was optimal for inflammation and pain relief in rodent models of arthritis. They stated that topical CBD application avoided first-pass metabolism and provided more constant plasma levels [46 ] .
The first pass effect happens when a substance or drug gets metabolized at a specific body location, resulting in the reduced active drug concentration when it reaches the site of action [47 ] .
To relieve neck pain and other spinal stenosis symptoms, topicals, like CBD cream s, balms, lotions , and salves, may be applied to the painful body part.
Some topicals have ingredients, like menthol and peppermint, which may be soothing, especially when massaged to the affected area.
CBD oils and tinctures may also be useful for individuals with spinal stenosis. Oils may be taken directly or mixed with food and beverages.
These oils may also be massaged into the painful areas. Meanwhile, tinctures (drops) may be applied under the tongue for added efficacy.
Some formats allow CBD to be ingested, such as pills, soft gels, edibles, and gummies.
These ingestible forms may be useful for individuals with spinal stenosis who need a convenient and consistent dosage of CBD.
CBD is available in a vape pen format. Inhalation of CBD may be useful for those with spinal stenosis who want to see instantaneous effects.
However, it may be hard to determine the exact CBD amounts when the substance is taken through vape. Lung problems are also associated with vaping [48 ] .
Understanding Spinal Stenosis
Spinal stenosis is characterized by the narrowing of spaces within the spine. This occurrence may add pressure to the nerves that travel through the spine. In most cases, the condition affects the lower back and neck [49 ] .
Some individuals do not exhibit spinal stenosis symptoms, while others experience pain, numbness, tingling sensations , and muscle weakness.
This medical condition is commonly caused by the wearing down of the spine, which is related to osteoarthritis.
Spinal stenosis is classified according to where it occurs in the spine. The two primary types are cervical stenosis (neck area) and lumbar stenosis (lower back area) [50 ] .
Cervical stenosis symptoms include [51 ] :
- Tingling sensations or numbness in the hand, arm, foot, or leg
- Weakness in the hand, arm, foot, or leg
- Walking and balancing problems
- Neck pain
- Bowel or bladder dysfunction (in more severe cases)
Meanwhile, lumbar stenosis symptoms include:
- Tingling sensations or numbness in the foot or leg
- Foot or leg weakness
- Pain or cramping on the legs after a person walks or stands for a long time
- Back pain
Lumbar Spinal Stenosis vs. Ruptured Disc
Lumbar spinal stenosis is different from a ruptured disc. A ruptured disc, or an intervertebral disc that has undergone herniation , pinches one or two nerves at a time. The pain caused by a herniated disc at the L4-S2 nerve roots is known as sciatica [52 ] .
Sciatica, which causes back pain that affects the leg, may happen at any time. This occurrence is different from pain experienced during stenosis, which happens when those with the condition stand or start walking.
During the passage of the 2018 Farm Bill, hemp was removed from the controlled substances act of the US Drug Enforcement Administration [53 ] . Hence, federal laws allow the production and marketing of hemp.
The law defines industrial hemp as any part of the Cannabis sativa plant that contains less than 0.30% of THC on a dry weight basis. Therefore, CBD is legal under federal laws.
Meanwhile, THC, which is being promoted by marijuana doctors for medical use, is not legal in all US states [54 ] .
Under the DEA, marijuana, heroin (an opiate ), lysergic acid diethylamide (LSD), ecstasy, peyote, and methaqualone are listed as schedule I drugs or substances [55 ] .
Schedule I substances are not accepted for medical use. They also have a high potential for abuse.
Currently, there are no studies on CBD’s effects on spinal stenosis. However, research found that CBD might have therapeutic benefits on symptoms related to the medical condition.
Researchers discovered that CBD might help with back pain, neuropathic pain, anxiety, depression, and other spinal stenosis symptoms.
For spinal stenosis, topical or transdermal CBD is recommended. Other formats, such as CBD oils and tinctures, may also be useful.
Further research on CBD as a potential treatment for spinal stenosis is warranted.
Before taking CBD for any medical condition, individuals are encouraged to speak to medical professionals first.