Best CBD Oil For Lung Cancer

CBDISTILLERY

Buy CBD Oil Online

Striking lung cancer response to self-administration of cannabidiol: A case report and literature review This article is distributed under the terms of the Creative Commons CBD oil can be used to help alleviate the symptoms and side effects of cancer treatments. However, there has been limited research on whether CBD oil can cure or be used to treat cancer to date. Lung cancer and the use of CBD oil, THC, and Marijuana for lung cancer patients is discussed by Dr. Ross Camidge and Matt Arensdorf, patient and advocate.

Striking lung cancer response to self-administration of cannabidiol: A case report and literature review

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

Abstract

In spite of new drugs, lung cancer is associated with a very poor prognosis. While targeted therapies are improving outcomes, it is not uncommon for many patients to have only a partial response, and relapse during follow-up. Thus, new drugs or re-evaluation of existing therapies used to treat other non-malignant diseases (drug repurposing) are still needed. While this research both in vitro and in vivo is being carried out, it is important to be attentive to patients where the disease responds to treatments not considered standard in clinical practice. We report here a patient with adenocarcinoma of the lung who, after declining chemotherapy and radiotherapy, presented with tumour response following self-administration of cannabidiol, a non-psychoactive compound present in Cannabis sativa. Prior work has shown that cannabidiol may have anti-neoplastic properties and enhance the immune response to cancer. The data presented here indicate that cannabidiol might have led to a striking response in a patient with lung cancer.

Introduction

The quest to improve the prognosis of lung cancer has led to the development and evaluation of new drugs with mechanisms of action that differ from those of conventional chemotherapy drugs used for many years worldwide. Great effort is now being placed in developing and assessing the potential of targeted therapies and immunotherapy in lung cancer which are leading to improved clinical outcomes. 1 Thus, targeted therapy is replacing conventional chemotherapy as standard treatment for patients with targetable oncogenic drivers. 2 However, it has to be acknowledged that responses to these agents are still partial with tumours recurring during follow-up. In fact, due to tumours’ genetic heterogeneity, a complete response in lung cancer patients is very difficult to achieve. 2

The challenge to improve the outcome of patients with lung cancer is leading to the evaluation of alternative drugs which, alone or in combination, may lead to improved response and survival in patients with lung cancer. Therefore, further development of new drugs or even established therapies previously used to treat non-malignant diseases (drug repurposing) which could have shown an effect on lung cancer in vitro and/or in vivo are worth pursuing.

One possible example is cannabidiol (CBD), a non-psychoactive compound from Cannabis sativa. CBD, which has been used in the management of several non-oncological pathologies, 3 could be a potential drug in the treatment of cancer. CBD has been shown to have anti-neoplastic effects in vitro and/or in vivo in lung cancer 4 –9 and other types of cancer. 10,11 However, although work is needed to better understand the mechanism/s of action of CBD both in vitro and in vivo, it is worth identifying any possible cases of patients with lung cancer whose disease responds to this drug. On this basis, we present here the case of a lung cancer patient whose tumour markedly responded to CBD.

In October 2016, an 81-year-old man with chronic obstructive pulmonary disease (COPD) presented to his general practitioner with a 3-week history of increasing breathlessness but no cough. A chest radiograph identified a shadow in the lower zone in the left lung, and subsequent CT scan confirmed the presence of a 2.5 × 2.5 cm mass in the lower left lung and multiple mediastinal lymph nodes ( Figure 1(a) and ( ​ (b)). b )). The patient underwent an endobronchial ultrasound guided biopsy of the paratracheal lymph nodes which revealed lung adenocarcinoma (T1c N3 M0). Tumour cells were strongly positive for CK7, thyroid transcription factor-1 (TTF-1) and with moderate focal expression of estrogen receptor (ER). They were negative for CK20, S100, PSA, CD56, synaptophysin and chromogranin. The tumour was negative for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutations.

CT scan image at diagnosis: (a) irregular rounded tumour seen in the periphery of left lower lobe, and (b) prominent multiple scattered mediastinal lymph nodes.

His previous medical history was COPD, diet controlled diabetes, and cancer of the prostate treated with radical prostatectomy in 2004 and in remission. He was not on regular medication and had no history of drug allergies. He was a retired salesman. There was no previous history of asbestos exposure. He was an ex-smoker (around 18 cigarettes daily for around 15 years) having stopped smoking 45 years ago. His ECOG performance status was 1. Physical examination was unremarkable.

The patient was offered chemotherapy and radiotherapy, but he declined as he was in his 80s and did not want any treatment that could adversely affect his quality of life. The decision was made to follow the patient up but without active treatment.

A CT scan in December 2016 showed that the lung mass had increased in size to 2.7 × 2.8 cm though the mediastinal and left hilar lymph nodes had not changed in size. The patient was offered treatment but again declined. A chest X-ray in July 2017 showed progressive changes in the left lower zone but no significant collapse or effusion evident. The patient had a further CT scan in November 2017 which revealed near total resolution of the left lower lobe mass with only a small area of residual spiculated soft tissue remaining (1.3 × 0.6 cm) and a significant reduction in size and number of mediastinal lymph nodes ( Figure 2(a) and ( ​ (b)). b )). The patient underwent another CT scan in January 2018 which showed stable appearances of the small residual opacity in the left lower lobe and mediastinal lymph nodes.

CT Scan image following the patient taking CBD: (a) marked regression of the left lower lobe mass leaving a small irregular residual linear band, and (b) striking regression of the mediastinal lymph nodes.

See also  Do CBD Gummies Make You Sleepy

On further questioning, the patient stated that he had started taking CBD (“MyCBD”) oil 2% (200 mg CBD in 10 mL) from the beginning of September 2017. He took two drops (0.06 mL, 1.32 mg CBD) twice daily for a week and then nine drops (0.3 mL, 6 mg CBD) twice daily until the end of September. Following the November 2017 CT scan, the patient started taking nine drops twice daily but had to stop around a week later. The reason behind this was that the patient did not like the taste and caused him slight nausea. He was never physically sick. There were no other changes in the patient’s diet, medication or lifestyle from September 2017. Informed written consent was obtained from the patient.

Discussion

The data presented here may indicate that CBD led to a partial tumour response in a patient with histologically proven adenocarcinoma of the lung. Various possible mechanisms of action leading to this objective response might be postulated.

It has been described that CBD can act on tumour cells, directly or indirectly, through different pathways and that these effects might vary in different tumour cells. CBD acts as an inverse agonist for CB2 receptor and an antagonist for CB1 receptor. 12 However, CBD has low affinity to either CB1 or CB2 receptors. 9 In addition, CBD has anti-cancer effects acting as an agonist for the transient receptor potential vanilloid (TRPV) 1 and 2 leading to changes in intracellular Ca 2+ levels. 5,13

It is also reported that CBD can induce apoptosis in cancer cells via the production of reactive oxygen species (ROS), caspase activation 4,13,14 and activation of p53 dependent apoptotic pathways in cancer cells 14,15 and down-regulation of mammalian target of rapamycin (mTOR) and cyclin D1. 16 CBD can also upregulate TNF/TNFR1 and TRAIL/TRAIL-R2 signalling by modulation of both ligand and receptor levels followed by apoptosis. 14 Furthermore, CBD inhibits human umbilical vein endothelial cells (HUVEC) endothelial cells migration, invasion and sprouting in vitro, and angiogenesis in vivo through down-modulation of several angiogenesis-related molecules. 17

From the immunological point of view, CBD significantly inhibits the recruitment of tumour-associated macrophages (TAM) in primary tumour stroma and secondary lung metastases. 12 CBD enhanced the susceptibility of cancer cells to adhere to and subsequently be lysed by Lymphokine-Activated Killer (LAK) cells, with both effects being reversed by a neutralizing ICAM-1 antibody. 9

Based on these data, it is clear that several factors may have been involved in this patient’s response to CBD. However, although significantly lower potency in non-malignant cells has been described, 18 the effects of CBD on non-malignant cells has yet to be fully assessed.

Conclusion

In summary, the data presented here indicate that CBD may have had a role in the striking response in a patient with histologically proven adenocarcinoma of the lung as a result of self-administration of CBD oil for a month and in the absence of any other identifiable lifestyle, drug or dietary changes. Further work is needed both in vitro and in vivo to better evaluate the various mechanisms of action of CBD on malignant cells, and its potential application in the treatment of not only lung cancer but also other malignancies.

Footnotes

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Ethical approval: Our institution does not require ethical approval for reporting individual cases or case series.

Funding: The author(s) received no financial support for the research, authorship, and/or publication of this article.

Informed consent: The patient described herein had given consent to the use of de-identified patient data for use in research and education. Written informed consent was obtained from the patient for his anonymized information to be published in this article.

References

1. Rotow J, Bivona TG. Understanding and targeting resistance mechanisms in NSCLC . Nat Rev Cancer 2017; 17 ( 11 ): 637–658. [PubMed] [Google Scholar]

2. Mayekar MK, Bivona TG. Current landscape of targeted therapy in lung cancer . Clin Pharmacol Ther 2017; 102 ( 5 ): 757–764. [PubMed] [Google Scholar]

3. Rong C, Lee Y, Carmona NE, et al. Cannabidiol in medical marijuana: research vistas and potential opportunities . Pharmacol Res 2017; 121 : 213–218. [PubMed] [Google Scholar]

4. Choi WH, Park HD, Baek SH, et al. Cannabidiol induces cytotoxicity and cell death via apoptotic pathway in cancer cell lines . Biomol Ther 2008; 16 : 87–94. [Google Scholar]

5. Ramer R, Rohde A, Merkord J, et al. Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells . Pharm Res 2010; 27 ( 10 ): 2162–2174. [PubMed] [Google Scholar]

6. Ramer R, Merkord J, Rohde H, et al. Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases . Biochem Pharmacol 2010; 79 ( 7 ): 955–966. [PubMed] [Google Scholar]

7. Preet A, Qamri Z, Nasser MW, et al. Cannabinoid receptors, cb1 and cb2, as novel targets for inhibition of non–small cell lung cancer growth and metastasis . Cancer Prev Res (Phila) 2011; 4 ( 1 ): 65–75. [PMC free article] [PubMed] [Google Scholar]

8. Ramer R, Bublitz K, Freimuth N, et al. Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1 . FASEB J 2012; 26 ( 4 ): 1535–1548. [PubMed] [Google Scholar]

9. Haustein M, Ramer R, Linnebacher M, et al. Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1 . Biochem Pharmacol 2014; 92 ( 2 ): 312–325. [PubMed] [Google Scholar]

10. Sayeda Y-K, Moreau M, Mueller R, et al. Enhancing the therapeutic efficacy of cancer treatment with cannabinoids . Front Oncol 2018; 8 ( 114 ): 1–8. [PMC free article] [PubMed] [Google Scholar]

11. Dumitru CA, Sandalcioglu IE, Karsak M. Cannabinoids in glioblastoma therapy: new applications for old drugs . Front Mol Neurosci 2018; 11 : 159–157. [PMC free article] [PubMed] [Google Scholar]

12. Elbaz M, Nasser MW, Ravi J, et al. Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of cannabidiol in breast cancer . Mol Oncol 2015; 9 ( 4 ): 906–919. [PMC free article] [PubMed] [Google Scholar]

13. Ligresti A, Moriello AS, Starowicz K, et al. Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma . J Pharmacol Exp Ther 2006; 318 ( 3 ): 1375–1387. [PubMed] [Google Scholar]

See also  What Do CBD Gummies Do Reddit

14. Ivanov VN, Wu J, Hei TK. Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways . Oncotarget 2017; 8 ( 43 ): 74068–74095. [PMC free article] [PubMed] [Google Scholar]

15. De Petrocellis L, Ligresti A, Moriello AS, et al. Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms . Br J Pharmacol 2013; 168 ( 1 ): 79–102. [PMC free article] [PubMed] [Google Scholar]

16. Sultan AS, Marie MA, Sheweita SA. Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines . Breast 2018; 41 : 34–41. [PubMed] [Google Scholar]

17. Ramer R, Fischer S, Haustein M, et al. Cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells . Biochem Pharmacol 2014; 91 ( 2 ): 202–216. [PubMed] [Google Scholar]

18. Nabissi M, Morelli MB, Santoni M, et al. Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agent . Carcinogenesis 2013; 34 ( 1 ): 48–57. [PubMed] [Google Scholar]

CBD Oil for Lung Cancer: Is Cannabis A Potential Treatment?

Lung cancer is the second most common form of cancer in the U.S. Sadly, it is estimated that more than 130,000 Americans will succumb to lung cancer in 2021.

Traditional treatments are widely regarded as being extremely difficult and painful to undergo. This fact, combined with the deadly threat posed by cancer, has contributed to a surge in research into new therapies and treatments for cancer worldwide.

One such area in treating cancer is the promising use of CBD oil. Several research studies have provided insight that using CBD oil may help prevent cancer growth. While more research is needed in this area, CBD oil is already being used to help manage the symptoms of cancer and the adverse health effects of various cancer treatments.

Are All Cannabis Oils the Same?

There are many different types of cannabis oils:

CBD Oil. This oil is nonpsychoactive, meaning that it will not produce any feeling of being “high.” This is due to the fact that CBD oil doesn’t contain THC, which is the compound responsible for giving users such a sensation. CBD is valued for its many health benefits, which include easing pain, anxiety, and the side effects of going through chemotherapy.

There are three main types of CBD oil:

  • Broad-spectrum CBD oil
  • Full-spectrum CBD oil
  • CBD oil derived from CBD isolate

Hemp Seed Oil. Hemp is a plant that is very similar to cannabis, with the key difference being that it does not contain THC or other important cannabinoids. Hemp seed oil is mainly used in skincare products or as a cooking oil.

Marijuana-derived oil. This type of oil is made from dried marijuana buds and leaves. As a result, it has a higher ratio of THC than other types of cannabis oils like CBD oil or hemp-derived oil.

Rick Simpson Oil. This type of oil features high levels of THC with a varying CBD content depending on the formulation.

For Health and Safety, Choose CBD Oil

When you’re looking for health benefits, it is CBD you want to emphasize when choosing a cannabis oil. Broad-spectrum CBD oil does not contain any THC, whereas full-spectrum CBD oil will have some THC present — but not more than 0.3%. CBD oil made from isolate involves a process of extracting all compounds from the cannabis plant. This process produces pure CBD in a crystal form which may be ground into a powder so that products are more convenient for consumption.

Can You Use CBD Oil to Treat Cancer?

There has been a push for research on whether CBD oil can help cure cancer. To date, there are many reports that CBD has helped people in dealing with this disease. But most of these reports are anecdotal evidence rather than scientific research. There isn’t any way to confirm the reliability of these stories or whether other treatments may have contributed to these positive experiences.

Most of the scientific research is still in its early stages in exploring whether CBD use is an effective cancer treatment. But there have been some positive findings.

A 2019 study found that CBD and cannabis extracts may cause the death of cancerous cells and may enhance the efficacy of radiation treatment. Other studies have also found that CBD in conjunction with THC may improve the effectiveness of radiation treatment in patients.

A specific case was reported in 2019 concerning a man with lung cancer. He declined traditional treatments and opted for the use of CBD oil instead. His tumor seemed to react favorably to CBD oil treatment.

But it is too early to definitively declare that CBD has any positive effects on preventing or treating lung cancer.

However, there are other areas in which the use of CBD oil can help people cope with lung cancer.

Does the Use of CBD Oil Help with Cancer Symptoms?

It is difficult to say whether CBD oil can help in cancer treatment, given that there is limited research in this area. However, there are various research findings that suggest CBD use can be extremely valuable for patients dealing with cancer and cancer treatments.

Cancer treatment typically involves chemotherapy or radiation therapy. Both of these treatment options take a heavy toll on the human body.

The use of CBD oil can help with various side effects of lung cancer treatment, including:

  • Pain
  • Fatigue
  • Reduced appetite
  • Nausea

CBD has been found to provide relief from chronic pain. This benefit of CBD use can be extremely valuable for cancer patients undergoing intense chemotherapy or radiation treatments.

Nausea is another common side effect of cancer treatment options. CBD has been found to lower the symptoms of nausea resulting from chemotherapy.

Does CBD Oil Use Come with any Side Effects?

CBD oil is generally safe to take. When using CBD, the side effects are predominantly mild and may include:

  • Dry mouth
  • Drowsiness
  • Diarrhea
  • Anxiety
  • Changes in appetite

Like any compound, CBD oil may interact with any medication you are currently taking. As a precaution, you should consult with your doctor if you are considering using CBD while already taking prescription medication.

See also  Buy CBD Oil Online Australia

How Is CBD Oil Used?

Products infused with CBD generally fall into one of four categories that depend on the way they are used.

Ingesting CBD

There are many benefits to consuming CBD, which may help explain why there are so many options to choose from on the market today. Ingesting these products means that the CBD passes through your digestive system and gets metabolized by your liver. This enables the CBD you ingest to be provided all over your body over a period of a few hours.

Products in this category include capsules, tinctures, or drops and can be added to food or mix with coffee or tea.

Sublingual CBD

Alternatively, you can take CBD oil using a sublingual method. This involves placing a few drops of CBD oil under your tongue and holding it there for up to 60 seconds. This method allows the important compounds to be quickly absorbed into your bloodstream and dispersed throughout your body.

Topical CBD

To reduce any inflammation or relieve the pain you may experience, look for topical CBD products as they work the best. They give you the flexibility to apply them directly to whichever parts of your body need some relief. Topical CBD products include salves, shampoos, lip balms, creams, patches, suppositories, personal lubricants, and bath salts.

Inhaled CBD

Another popular way to take CBD is to inhale its vapors using vape carts and pens. This way, CBD enters your bloodstream quickly through your lungs and avoids the digestive system altogether. In particular, vaping has been growing in popularity with CBD use due to its ease of use and variety of flavors and options.

For CBD use with lung cancer, it is important to discuss your options with your doctor. This is particularly important for inhaling CBD.

Where Can I Buy CBD Oil?

With the passing of the 2018 Farm Bill, cannabis products are legal, theoretically, at the federal level as long as they contain less than 0.3% Delta 9 THC. As a result, many dispensaries and stores now carry a wide selection of CBD oils and other products.

If you prefer the many advantages of online shopping for your CBD oil, you have countless options to choose from. But keep in mind that CBD oils, for the most part, are largely unregulated. Therefore, you need to guarantee that your product is safe and effective.

According to a recent study, less than one in three CBD products that were sold online had a correct label, with many of these products having less CBD content than advertised or had a significant concentration of THC.

So be sure to carefully research the company and its products before buying.

Key Takeaways on Using CBD Oil for Lung Cancer

There isn’t enough research to declare that CBD oil is effective as a treatment option for cancer. However, CBD may be able to offer some relief from the side effects of traditional treatments and from the symptoms of cancer.

It is a good idea to continue following the advice of your health care provider, even if your CBD oil seems to be giving you positive effects. Otherwise, stopping ongoing procedures could make future treatments more difficult and negatively impact your ability to treat tumors.

CBD oil is a promising ally in your battle with lung cancer. As more research becomes available, CBD oil may prove to be a viable treatment for your health needs.

References:

  1. Dariš, B., Tancer Verboten, M., Knez, Ž., & Ferk, P. (2019). Cannabinoids in cancer treatment: Therapeutic potential and legislation. Bosnian journal of basic medical sciences, 19(1), 14–23.(1)
  2. Ivanov, V. N., Wu, J., Wang, T., & Hei, T. K. (2019). Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells. Oncotarget, 10(8), 825–846.(2)
  3. Scott K., Dalgleish A, & Liu W. (2014).The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model. Mol Cancer Ther December 1 2014 (13) (12) 2955-2967; DOI: 10.1158/1535-7163.MCT-14-0402 (3)
  1. Sulé-Suso1 J., 2, Watson N., van Pittius D., & Jegannathen A. (2019). Striking lung cancer response to self-administration of cannabidiol: A case report and literature review. Sage Open Medical Case Reports.First Published February 21, 2019. (4)
  2. Argueta, D. A., Ventura, C. M., Kiven, S., Sagi, V., & Gupta, K. (2020). A Balanced Approach for Cannabidiol Use in Chronic Pain. Frontiers in pharmacology, 11, 561. (5)
  3. Rock, E. M., Sticht, M. A., Limebeer, C. L., & Parker, L. A. (2016). Cannabinoid Regulation of Acute and Anticipatory Nausea. Cannabis and cannabinoid research, 1(1), 113–121.(6)
  4. Bonn-Miller, M., Loflin, M., Thomas, B., Marcu,J., Hyke, T., Vandrey, R. (2017) Labeling Accuracy of Cannabidiol Extracts Sold Online. JAMA. 2017;318(17):1708-1709. doi:10.1001/jama.2017.11909 (7)
Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

CBD and Lung Cancer | Hope With Answers℠

Learn about CBD oil, THC, and Marijuana and their uses for lung cancer patients through this discussion between Dr. Ross Camidge of the University of Colorado Medical Center and Matt Arensdorf, lung cancer patient and advocate:

  • Learn the basics about the differences between THC and CBD and how that relates to marijuana.
  • Can CBD oil be used to help lung cancer patients?
  • What can CBD be used for?
  • Is CBD a treatment for lung cancer?
  • Can CBD help relieve pain associated with lung cancer?
  • How can I get CBD – do I need a prescription?
  • Where can I get a CBD product?
  • What type of product is best – edibles? Oils? Something smoked?

The Hope With Answers℠ Intro video series discusses the use of CBD oil for lung cancer. Dr. Ross Camidge of the University of Colorado Medical Center and Matt Arensdorff, lung cancer patient advocate. provides basic information for those newly diagnosed with lung cancer. Start your journey of understanding and learn more about the importance of detecting lung cancer early and methods for detection and treatment.

How useful was this post?

Click on a star to rate it!

Average rating / 5. Vote count:

No votes so far! Be the first to rate this post.